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Models

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Mice

hPD-L1/hOX40

Strain Name：C57BL/6Smoc-Cd274em1(hPD-L1)Tnfrsf4em1(hTNFRSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00111

hPD-L1（NM-HU-00062）was crossed with hOX40（NM-HU-00041）to generate hPD-L1/hOX40.

Mice

hTIM3

Strain Name：C57BL/6Smoc-Havcr2em1(hHAVCR2)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00054

The endogenous mouse Tim3 gene was replaced by human TIM3 gene .

Mice

A1bg-Flox

Strain Name：C57BL/6Smoc-A1bgem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of A1bg gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A1bg gene.

Mice

hCRBN

Strain Name：C57BL/6Smoc-Crbntm1(hCRBN)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225071

The endogenous mouse Crbn gene was replaced by human CRBN gene.

Mice

hVSIG4

Strain Name：C57BL/6Smoc-Vsig4em1(hVSIG4)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210004

The endogenous mice Vsig4 gene was replaced by human VSIG4 gene

Mice

hIL12B

Strain Name：C57BL/6Smoc-Il12betm3(hIL12B)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000057

The endogenous mouse Il12b gene was replaced by human IL12B gene.

Mice

A1Cf-KO

Strain Name：C57BL/6Smoc-A1Cfem1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 4 of A1Cf gene was deleted to generate A1Cf knockout mice.

Mice

hCCR8(2)/hTIGIT

Strain Name：C57BL/6Smoc-Tigittm3(hTIGIT)Ccr8em3(hCCR8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220073

hTIGIT(NM-HU-200244) mice were crossed with hCCR8(2) (NM-HU-2000054) mice to generate hTIGIT/hCCR8 mice．

Mice

hCD80

Strain Name：C57BL/6Smoc-Cd80em1(hCD80) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00074

The endogenous mouse Cd80 gene was replaced by human CD80 gene .

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Fcgrtem1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

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