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Models

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Mice

hSTING

Strain Name：C57BL/6Smoc-Tmem173tm2(hTMEM173)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190036

The endogenous mouse Tmem173 gene was replaced by human TMEM173 gene.

Mice

hCD24

Strain Name：C57BL/6Smoc-Cd24atm1(hCD24)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000060

The endogenous mouse Cd24a gene was replaced by human CD24 gene. While hCD24(2)(Stock No.NM-HU-215025) mice function similarly to hCD24 mice, for more detailed information please contact our technical advisor.

Mice

hTLR9

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-18016

This TLR9 humanized mouse model was established by replacing the mouse Tlr9 gene exon2 with the human TLR9 corresponding sequence by homologous recombination.

Mice

Apoe-KO(2)

Strain Name：C57BL/6Smoc-Apoeem5Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190565

Apoe-KO(2) mice (Stock No.NM-KO-190565) carry a knockout allele derived from the targeted deletion of exon 2-4. While Apoe-KO mice (Stock No.NM-KO-00033) have been pulled from shelves for some reasons.

Mice

Scgb3a2-IRES-Cre

Strain Name：C57BL/6Smoc-Scgb3a2em1(IRES-Cre-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-210127

IRES-Cre-polyA expression cassette was knocked into the Scgb3a2 gene.

Mice

H11-CAG-RSR-EYFP

Strain Name：C57BL/6Smoc-Igs2em1(CAG-RSR-EYFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18056

A CAG-ROX-STOP-ROX-EYFP-V5tag-polyA conditional expression cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) . This strain of mice can be used to mate with mice expressing the Dre recombinase. After exposure to Dre recombinase, expression of ellow fluorescent protein and V5 tag is observed for cell tracking.

Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher).

Mice

Pdcd1-DTR-2A-tdTomato

Strain Name：C57BL/6Smoc-Pdcd1em1(DTR-2A-tdTomato-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200225

A DTR-2A-tdTomato-WPRE-pA expression cassette was knocked into the Pdcd1 gene start codon site.

Mice

hCALCRL

Strain Name：C57BL/6Smoc-Calcrlem1(hCALCRL)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225031

The endogenous mouse Calcrl gene was replaced by human CALCRL gene.

Mice

hCB1

Strain Name：C57BL/6Smoc-Cnr1em1(hCB1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225027

The endogenous mouse Cnr1 gene was replaced by human CB1 gene.

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