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Models

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Mice

hOX40(2)/hOX40L/hICOS

Strain Name：C57BL/6J-Tnfrsf4 em1(hTNFRSF4)Tnfsf4 em2(hTNFSF4)Icos em1(hICOS )Smoc
Strain State：Developing | Cat. NO.：NM-HU-252545

ICOS humanization was performed on the background of hOX40(2)/hOX40L mice using homologous recombination

Mice

HLA-B40.1/B2M

Strain Name：C57BL/6J- B2mem1(hB2M-linker-HLA-B*4001/H2-D1)Smoc
Strain State：Developing | Cat. NO.：NM-HU-252699

The endogenous mouse B2m gene was replaced by human HLA-B gene.

Mice

HLA-B58.1/B2M

Strain Name：C57BL/6J- B2mem1(hB2M-linker-HLA-B*5801/H2-D1)Smoc
Strain State：Developing | Cat. NO.：NM-HU-252700

The endogenous mouse B2m gene was replaced by human HLA-B gene.

Mice

HLA-B7.2/B2M

Strain Name：C57BL/6J-B2mem1(hB2M-linker-HLA-B*0702/H2-D1)Smoc
Strain State：Developing | Cat. NO.：NM-HU-252701

The endogenous mouse B2m gene was replaced by human HLA-B gene.

Mice

HLA-B39.1/B2M

Strain Name：C57BL/6J-B2mem1(hB2M-linker-HLA-B*3901/H2-D1)Smoc
Strain State：Developing | Cat. NO.：NM-HU-252702

The endogenous mouse B2m gene was replaced by human HLA-B gene.

Mice

MHC Class II (I-A/I-E) -KO

Strain Name：C57BL/6Smoc-H2-Ab1em1H2-Aaem1 H2-Eb1em1H2-Eb2em1H2-Ea-ps em1 Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18032

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the C57BL/6J genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

Wnt6-KO

Strain Name：C57BL/6JSmoc-Wnt6em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190693

Exon 2-3 of Wnt6 gene was deleted to generate Wnt6 knockout mice.

Mice

Irf7-KO

Strain Name：C57BL/6JSmoc-Irf7em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190826

Exon 5-10 of Irf7 gene was deleted to generate Irf7 knockout mice.

Mice

C57BL/6

Strain Name：C57BL/6Smoc
Strain State：Repository Live | Cat. NO.：SM-001

C57BL/6 mice have a high reproductive capacity, a long life span, and a low tumor susceptibility. Male mice are aggressive and fight frequently. Diet can cause obesity, type II diabetes, and atherosclerosis in these mice. The C57BL/6 mouse is the first to have its entire genome sequenced. It is the most extensively used inbred mouse strain as a genetic basis for congenic and mutant mice. It is also used in genetics, metabolism, immunology, neurology, behavioral research, pharmacodynamics, and medication safety evaluation.

Mice

Nnt-KO(C57BL/6NSmoc)

Strain Name：C57BL/6NSmoc-Nntem2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-251159

The exon 6 of Nnt gene was deleted to generate Nnt knockout mouse.

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