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Mice

C57BL/6

Strain Name：C57BL/6
Strain State：Repository Live | Cat. NO.：SM-001
Validation Data：Presence

It was the first mouse strain to have its genome sequenced. With black coat color, it is recognized as the "standard" inbred strain and provides genetic background for numerous mutant genes. It is characterized by stable strain properties, ease of breeding, uniform stress responses, and high precision in experimental results.

Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025
Publications：1piece

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher). *This strain is a client-donated line. The donor's publication indicates that fluorescence was observed by immunofluorescence. The JAX description of this strain also explicitly states that fluorescence cannot be directly observed.

Mice

Krtap4-6-KO

Strain Name：C57BL/6Smoc-Krtap4-6em1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 1 of Krtap4-6 gene was deleted to generate Krtap4-6 knockout mice.

Mice

Nkx2-6-KO

Strain Name：C57BL/6Smoc-Nkx2-6em1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 2 of Nkx2-6 gene was deleted to generate Nkx2-6 knockout mice.

Mice

Mill2-KO

Strain Name：C57BL/6Smoc-Mill2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200367

Exon 3-6 of Mill2 gene was deleted to generate Mill2 knockout mice.

Mice

Sympk-KO

Strain Name：C57BL/6Smoc-Sympkem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-191041

Exon 6 of Sympk gene was deleted to generate Sympk knockout mice.

Mice

G6pc-Flox

Strain Name：C57BL/6Smoc-G6pcem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200053

These mice carry loxP sites flanking exon 3 of G6pc gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of G6pc gene.

Mice

Abcb8-Flox

Strain Name：C57BL/6Smoc-Abcb8em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-253536

These mice carry loxP sites flanking exon 3-6 of Abcb8 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Abcb8 gene.

Mice

Gba-Flox

Strain Name：C57BL/6Smoc-Gbaem2(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200051

These mice carry loxP sites flanking exon 8-11 of Gba gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gba gene.While Gba-Flox(2)(Stock No.NM-CKO-200179)mice carrying the loxP sites flanking exon 6-8 of Gba gene.

Mice

Bmp1-Flox

Strain Name：C57BL/6Smoc-Bmp1em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200065

These mice carry loxP sites flanking exon 3-6 of Bmp1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Bmp1 gene.

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