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Disease Mouse Models (Non-genetically-engineered)

diseases mice diseases model non genetically modified organisms

Shanghai Model Organisms has established a library of typical mouse models of human diseases through surgery or drug induction, thereby providing useful animal models for the research on pathogenesis of related diseases, functional studies of genes or proteins in diseases, screening of disease drugs and evaluation of therapeutic effects, etc.

Services

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Shanghai Model Organisms offers a full range of model organism services, including model customization services, research-ready models, breeding, phenotyping and drug screening. Mouse, rat, zebrafish and C. elegans models are available to meet different research needs.

Breeding Services

We will delivery the specific genotype model product within specific period by natural breeding or assisted reproduction technology. The specified breeding technologies include natural breeding, assisted reproduction, SPF purification, etc.

モデルマウスの繁殖

カスタマイズされた後のモデル、またはお客様の既有の遺伝子組み換え動物モデルは、自然繁殖または補助的生殖繁殖の方法によって、特定周期に、特定遺伝子型モデル製品として提供されます。具体的には、自然繁殖、補助的生殖繁殖、 SPF精製等が含まれます。

모델 번식

특정 유전자 조합 모델 상품을 자연 번식 혹은 보조 생식하여 특정 시기에 납품됩니다. 이미 고객님이 보유한 유전자 변형 동물 모델 또한 자연 번식 혹은 보조 생식 서비스를 제공합니다.구체적 번식 기술: 자연 번식, 보조 생식, SPF 정화 등.

Overview of gene editing technology

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In Vivo Efficacy Evaluation

Some Basics about Cre-lox and Inducible Cre in Mouse Modeling

Mouse

transgenic mice mouse model editing mouse

Mice have long been the prime choice for model organisms. In more than 100 years, mice have been widely used by researchers in the fields of physiology, pathology, pharmacology, toxicology, and behavioral science. With the establishment of gene targeting technology, many researchers have made their way to the Nobel Prize.

Gene overexpression

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Generate a mouse model in which an exogenous gene is introduced and overexpressed. An overexpression model can be used to investigate gene functions, promoter functions, or model the pathogenesis of human disease. Depending on the method to introduce foreign DNA, a random transgenes or targeted conditional overexpression model can be created.