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Cckbr-KO

Strain Name：C57BL/6Smoc-Cckbr^em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190609

Exon 3 of Cckbr gene was deleted to generate Cckbr knockout mice.

R26-CAG-LSL-hSOD1*G94A-IRES-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sor^{tm1(CAG-FRT-LSL- SOD1(G94A)-IRES-EGFP-WPRE-pA)Smoc}
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200263

A CAG-FRT-LSL- SOD1(G94A)-IRES-EGFP-WPRE-pA expression cassette was knocked into the Rosa26 locus.

Mir29a/Mir29b1-KO

Strain Name：C57BL/6Smoc-Mir29a^em1 Mir29b-1^em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-00081

a 0.6kb region in length including Mir29a and Mir29b-1 pre-microRNAs was removed in this strain.

Lep-KO

Strain Name：B6;129S-Lep^tm1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-00034
Validation Data：Presence

Exon 2 was replaced by Neo cassette.

Foxp3-IRES-tdTomato-2A-Cre

Strain Name：C57BL/6Smoc-Foxp3^{em3(IRES-tdTomato-2A-iCre)Smoc}
Strain State：Repository Live | Cat. NO.：NM-KI-190119
Validation Data：Presence

A IRES-tdTomato-2A-Cre expression cassette was knocked into the Foxp3 gene stop codon site. This strain is useful in studying regulatory T cell in autoimmunity, especially in type 1 diabetes.

Nkx2-1-CreERT2

Strain Name：C57BL/6Smoc-Nkx2-1^{em1(CreERT2-pA)Smoc}
Strain State：Repository Live | Cat. NO.：NM-KI-200123
Validation Data：Presence

A CreERT2-pA expression cassette was knocked into the Nkx2-1 gene start codon site. Nkx2-1, a key molecule in lung development, is expressed in adult bronchial and alveolar type Ⅱ epithelial cells. Besides, Nkx2-1 expression as a prognostic marker is also been applied to lung cancer research including lung adenocarcinoma.

R26-CAG-LSL-Fto-IRES-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sor^{em1(CAG-LSL-3xFLAG-Fto-IRES-EGFP)Smoc}
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190055

These mice harbor a CAG-LSL-3xFLAG-Fto-IRES-EGFP cassette in the Rosa26 locus generated by homologous recombination.

Lepr-g.G109052T

Strain Name：B6.129S-Lepr^tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00001

A point mutation was introduced to exon 19 (c.109052 G>T) via a recombineering strategy. Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion.

Lep-KO(SD)

Strain Name：SD-Lep^em1Smoc Strain State：Repository Live | Cat. NO.：NR-KO-200001

Exon 2-3 of Lep gene was deleted to generate Lep knockout rat.

Harnessing the Power of the Cre-loxP System: Benefits, Challenges, and Applications

This webinar will introduce the Cre-loxP system, a powerful genetic tool that has revolutionized biological research by allowing for conditional gene knockout, knockdown, and overexpression. We will cover the history of the genetic recombination systems, discuss how they enable precise control of gene expression in specific cell types or at specific developmental stages, and present GenoBioTX’s genetically modified models utilizing this method.