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Mice

Npc1-KO

Strain Name：C57BL/6Smoc-Npc1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-205053

Exon 9 of Npc1 gene was deleted to generate Npc1 knockout mice.

Mice

Il13ra1-KO

Strain Name：C57BL/6Smoc-Il13ra1em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190457

Exon 2 of Il13ra1 gene was deleted to generate Il13ra1 knockout mice.

Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher).

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Iapp-KO

Strain Name：C57BL/6Smoc-Iappem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190664

Exon 3 of Iapp gene was deleted to generate Iapp knockout mice.

Mice

Cpe-KO

Strain Name：C57BL/6Smoc-Cpeem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190671

Exon 2 of Cpe gene was deleted to generate Cpe knockout mice.

Mice

Fah-KO(NMG)

Strain Name：NOD-PrkdcscidIl2rgem1Fahem2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-NSG-004

Exon 3 of Fah gene was deleted to generate Fah knockout mice.

Mice

Vcan-KO

Strain Name：C57BL/6Smoc-Vcanem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190564

Exon 2 of Vcan gene was deleted to generate Vcan knockout mice.

Mice

Gcdh-KO

Strain Name：C57BL/6Smoc-Gcdhem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200603

Exon 3-7 of Gcdh gene was deleted to generate Gcdh knockout mice.

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