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Models

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Mice

Atxn2-KO

Strain Name：C57BL/6Smoc-Atxn2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190920

Exon 6 of Atxn2 gene was deleted to generate Atxn2 knockout mice.

Mice

Chga-CreERT2

Strain Name：C57BL/6Smoc-Chgaem(CreERT2-Wpre-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-204993

CreERT2-Wpre-pA expression cassette was knocked into the Chga gene.

Mice

Adrb3-KO

Strain Name：C57BL/6Smoc-Adrb3em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190739

Exon 2 of Adrb3 gene was deleted to generate Adrb3 knockout mice.

Mice

Col2a1-2A-CreERT2

Strain Name：C57BL/6Smoc-Col2a1em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18029

A 2A-CreERT2 expression cassette was knocked into the stop codon of Col2a1 gene to establish a Col2a1-CreERT2 recombinase tool mouse.The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.

Mice

Nkx2-1-CreERT2

Strain Name：C57BL/6Smoc-Nkx2-1em1(CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200123

A CreERT2-pA expression cassette was knocked into the Nkx2-1 gene start codon site. Nkx2-1, a key molecule in lung development, is expressed in adult bronchial and alveolar type Ⅱ epithelial cells. Besides, Nkx2-1 expression as a prognostic marker is also been applied to lung cancer research including lung adenocarcinoma.

Mice

C57BL/6

Strain Name：C57BL/6Smoc
Strain State：Repository Live | Cat. NO.：SM-001

C57BL/6 mice have a high reproductive capacity, a long life span, and a low tumor susceptibility. Male mice are aggressive and fight frequently. Diet can cause obesity, type II diabetes, and atherosclerosis in these mice. The C57BL/6 mouse is the first to have its entire genome sequenced. It is the most extensively used inbred mouse strain as a genetic basis for congenic and mutant mice. It is also used in genetics, metabolism, immunology, neurology, behavioral research, pharmacodynamics, and medication safety evaluation.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

Dmp1-KO

Strain Name：C57BL/6Smoc-Dmp1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200634

Exon 4-6 of Dmp1 gene was deleted to generate Dmp1 knockout mice.

Mice

Sox10-KO

Strain Name：C57BL/6Smoc-Sox10em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200645

Exon 4-5 of Sox10 gene was deleted to generate Sox10 knockout mice.

Mice

Slc34a1-KO

Strain Name：C57BL/6Smoc-Slc34a1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200642

Exon 3-6 of Slc34a1 gene was deleted to generate Slc34a1 knockout mice.

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