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Models

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Mice

hPD-1/hCD3E

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd3eem1(hCD3E)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18021

hPD-1（NM-HU-00015）was crossed with hCD3E（NM-HU-00114）to generate hPD-1/hCD3E。

Mice

hIL2RA

Strain Name：C57BL/6Smoc-Il2ratm1(hIL2RA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190064

The endogenous mouse Il2ra gene was replaced by human IL2RA gene.

Mice

hPD-1/hSTING

Strain Name：C57BL/6Smoc-Tmem173tm1(hTMem173)Pdcd1em1(hPDCD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000104

hPD-1(NM-HU-00015) was crossed with hSTING(NM-HU-190036) to generate hPD-1/hSTING.

Mice

hCTLA-4/4-1BB

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4) Tnfrsf9em1(hTNFRSF9) /Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18020

This CTLA4 and 4-1BB double knockin strain is established by crossing CTLA4-HU and 4-1BB-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hCD73(2)

Strain Name：C57BL/6Smoc-Nt5etm3(NT5E)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200009

The endogenous mouse Nt5e gene was replaced by human NT5E gene.

Mice

hIL4/hIL4R

Strain Name：C57BL/6Smoc-Il4tm3(hIL4)Il4ratm1(hIL4R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000106

These mice are obtained through breeding of two single gene humanized mice.

Mice

hTLR2

Strain Name：C57BL/6Smoc-Tlr2em2(hTLR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190066

The endogenous mouse Tlr2 gene was replaced by human TLR2 gene.

Mice

hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47em1(hCD47)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000111

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

hPD-1/hSEMA4D

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Sema4dem1(hSemA4D)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190033

hPD-1(NM-HU-00015) was crossed with hSEMA4D(NM-HU-00117) to generate hPD-1/hSEMA4D.

Mice

hPD-1/hTIM3

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Havcr2em1(hHAVCR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00103

hPD-1(NM-HU-00015) was crossed with hTIM3(NM-HU-00054)to generate hPD-1/hTIM3 mice

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