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Models

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Mice

hGLP1R

Strain Name：C57BL/6Smoc-Glp1rtm2(hGLP1R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200220
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Glp1r gene was completely or partially replaced by human hGLP1R gene via CRISPR/Cas9 mediated recombination.

Mice

hCTLA-4

Strain Name：C57BL/6Smoc-Ctla4tm1(hCTLA4) Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00014
Validation Data：Presence

The endogenous mouse Ctal4 gene was replaced by human CTLA4 gene. While hCTLA4(2)(Stock No.NM-HU-190038) mice function similarly to hCTLA4 mice,for more detailed information please contact our technical advisor.

Mice

hPD-L1/hCD28

Strain Name：C57BL/6Smoc-Cd274tm1(hPD-L1)Cd28tm2(hCD28)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210019

hPD-L1(NM-HU-00062) was crossed with hCD28(NM-HU-190011) to generate hPD-L1/hCD28 mice

Mice

hPD-1/hCTLA-4

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Ctla4tm1(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00079
Validation Data：Presence

hPD-1(NM-HU-00015) was crossed with hCTLA4(NM-HU-00014)to generate hPD-1/hCTLA4 mice

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-hFcRn)Fcgrtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109
Validation Data：Presence  |  Publications：1piece

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

Pten-KO

Strain Name：C57BL/6Smoc-Ptenem3Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18002

Exon5 of Pten gene was deleted to generate Pten knockout mice.

Mice

R26-CAG-LSL-hEGFR*L858R/T790M-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LSL-EGFR (L858R-T790M)-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190068

These mice harbor a CAG-LSL-EGFR (L858R-T790M)-IRES-luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.

Mice

hCD80

Strain Name：C57BL/6Smoc-Cd80tm1(hCD80) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00074
Validation Data：Presence

The endogenous mouse Cd80 gene was replaced by human CD80 gene .

Mice

hTSLP

Strain Name：C57BL/6Smoc-Tslptm2(hTSLP)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000064
Validation Data：Presence

The endogenous mouse Tslp gene was replaced by human TSLP gene.

Mice

hOX40(2)

Strain Name：C57BL/6Smoc-Tnfrsf4tm3(hTNFRSF4) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00078
Validation Data：Presence

The exon1-5 and partial exon6 of endogenous mouse Tnfrsf4(Ox40) gene was replaced by the corresponding region of human TNFRSF4(OX40) gene. While hOX40(Stock No.NM-HU-00041) mice function similarly to hOX40(2) mice,for more detailed information please contact our technical advisor.

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