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Models

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Mice

hTSLP

Strain Name:C57BL/6Smoc-Tslptm2(hTSLP)/Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-2000064

The endogenous mouse Tslp gene was replaced by human TSLP gene.

Mice

R26-CAG-LSL-HPV-E6-CAG-LSL-HPV-E7-IRES-Luc

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-HPV-E6-CAG-LSL-HPV-E7-IRES-Luciferase)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-200257

A CAG-LSL-HPV-E6-CAG-LSL-HPV-E7-IRES-Luciferase expression cassette was knocked into the Rosa26 locus.

Mice

Trp53-Flox

Strain Name:C57BL/6Smoc-Trp53tm2(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-18005

These Trp53 flox mice possess loxP sites flanking exons 5-7 via ESC targeting. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

hPD-1/hOX40

Strain Name:C57BL/6Smoc-Pdcd1em1(hPDCD1)Tnfrsf4em3(hTNFRSF4) Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-00108

hPD-1(NM-HU-00015)was crossed with hOX40(NM-HU-00041)to generate hPD-1/hOX40.

Mice

hHBB

Strain Name:C57BL/6Smoc-Hbb-bt&Hbb-bstm1(hHBB)/Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-2000080

The endogenous mouse Hbb-bt and Hbb-bs gene was replaced by human HBB gene.

Mice

hPD-L1/hOX40

Strain Name:C57BL/6Smoc-Cd274em1(hPD-L1)Tnfrsf4em1(hTNFRSF4)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-00111

hPD-L1(NM-HU-00062)was crossed with hOX40(NM-HU-00041)to generate hPD-L1/hOX40.

Mice

hCD80

Strain Name:C57BL/6Smoc-Cd80em1(hCD80) Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-00074

The endogenous mouse Cd80 gene was replaced by human CD80 gene .

Mice

hFCRN

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Fcgrtem1/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-00109

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032)mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

hOX40(2)

Strain Name:C57BL/6Smoc-Tnfrsf4em3(hTNFRSF4) Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-00078

The exon1-5 and partial exon6 of endogenous mouse Tnfrsf4(Ox40) gene was replaced by the corresponding region of human TNFRSF4(OX40) gene. While hOX40(Stock No.NM-HU-00041) mice function similarly to hOX40(2) mice,for more detailed information please contact our technical advisor.

Mice

hPD-1/hCTLA-4

Strain Name:C57BL/6Smoc-Pdcd1em1(hPDCD1)Ctla4em1(hCTLA4)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-00079

hPD-1(NM-HU-00015) was crossed with hCTLA4(NM-HU-00014)to generate hPD-1/hCTLA4 mice

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