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Models

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Mice

Gba-Flox

Strain Name：C57BL/6Smoc-Gbaem2(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200051

These mice carry loxP sites flanking exon 8-11 of Gba gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gba gene.While Gba-Flox(2)(Stock No.NM-CKO-200179）mice carrying the loxP sites flanking exon 6-8 of Gba gene.

Mice

Gla-KO

Strain Name：C57BL/6Smoc-Glaem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-200601

Exon 2-3 of Gla gene was deleted to generate Gla knockout mice.

Mice

BALB/c

Strain Name：BALB/cAnSmoc
Strain State：Repository Live | Cat. NO.：SM-003

BALB/c is one of the most widely used inbred lines in biomedical research, especially in immunology and infectious disease research. The incidence of breast tumors is about 10% to 20%. There is a certain number of ovarian, adrenal, pulmonary tumors, and leukemia that occurs. Lung cancer occurs in 26% of female mice and 29% of male mice. The incidence of leukemia is 12% in females and 10% in males. Blood pressure was the highest compared to other inbred mice and had spontaneous hypertension.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

hAppNL-G-F

Strain Name：C57BL/6Smoc-Apptm3(hAppNL-G-F)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000088

The endogenous mouse App gene was replaced by human AppNL-G-F.

Mice

hAppNL-F

Strain Name：C57BL/6Smoc-Apptm3(hAppNL-F)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000087

The endogenous mouse App gene was replaced by human AppNL-F.

Mice

hTREM2

Strain Name：C57BL/6Smoc-Trem2em4(hTRem2)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000083

The endogenous mouse Trem2 gene was replaced by human TREM2 gene.

Mice

Ide-KO

Strain Name：C57BL/6Smoc-Ideem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190821

Exon 3 of Ide gene was deleted to generate Ide knockout mice.

Mice

Ldlr-C223R

Strain Name：C57BL/6Smoc-Ldlrem1(C223R)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00043

These mice carry a C223R mutation in Ldlr gene via CRISPR/Cas mediated recombination.

Mice

Il1a-KO

Strain Name：C57BL/6Smoc-Il1aem2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190474

Exon 5-6 of Il1a gene was deleted to generate Il1a knockout mice.

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