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Models

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Mice

Cdkn2a/Cdkn2b-KO(p15/p16/p19-KO)

Strain Name：C57BL/6Smoc-Cdkn2aemCdkn2bem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-241617

The p15/p16/p19-KO mouse model was established by knocking out all genomic regions between exon1 of the p15 gene and exon1 of the p16 gene.

Mice

Cd68-2A-Cre

Strain Name：C57BL/6Smoc-Cd68em5(2A-Cre-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200192

This Cd68-Cre tool mouse model was established by inserting a 2A-Cre-WPRE-polyA co-expression cassette into the stop codon of Cd68 gene .

Mice

Slc17a6-CreERT2

Strain Name：C57BL/6Smoc-Slc17a6em2(CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190011

This tamoxifen-inducible Slc17a6-CreERT2 tool mouse model was established by inserting a 2A-CreERT2-WPRE-polyA co-expression cassette into the stop codon of Slc17a6 gene.

Mice

Npc1-I1060T

Strain Name：C57BL/6Smoc-Npc1em1(I1060T)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18059

The I1060T point mutation is located in exon21 of mouse Npc1 gene. This Npc1 point mutation mouse model was established by introduce a T>C transversion at the 138th nucleotide of exon21.

Mice

Gba-D427V

Strain Name：C57BL/6Smoc-Gbaem1(D427v)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18060

The D427V point mutation is located in exon9 of mouse Gba gene. This Gba point mutation mouse model was established by introduce an A>T transversion at the 119th nucleotide of exon9.

Mice

Cdkn2a/Cdkn2b-Flox(p15/p16-Flox)

Strain Name：C57BL/6Smoc-Cdkn2a/Cdkn2bem2(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-250099

On the basis of Cdkn2b-Flox(NM-CKO-2115067), a p15/ P16-Flox mouse model was obtained by inserting loxP on both sides of Cdkn2b(p15) gene exon 2 and lox2272 on both sides of Cdkn2a(p16) gene exon1. The flox region of these strains is exon2 of p15 gene and exon1 of p16 gene.

Mice

F9-KO

Strain Name：C57BL/6Smoc-F9em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18046

The F9 gene is located on the X chromosome. In this F9 knockout mouse model, gRNAs were designed targeting Exon8 of F9 gene via CRISPR gene editing technology. Loss of F9 caused coagulopathy in mice. Mice that are homozygous for F9 knockout are viable, fertile and normal in size. Normal fighting in the cage may cause bleeding or even death due to massive internal hemorrhaging. After the tail cutting, wounds must be cauterized to prevent homozygous knockout mice from blood loss and death. This strain is a powerful model for studying coagulopathy, gene therapy methods and function of factor IX mutations. F9-KO mice (Stock No.NM-KO-18046）carry a knockout allele derived from the targeted deletion of exon 8. While F9-KO(2) mice (Stock No.NM-KO-200607) carrying the exon 1-8 deletion.

Mice

Cd274-KO(2)

Strain Name：C57BL/6Smoc-Cd274em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18044

Cd274 gene is also called B7-H1, Pdcd1lg1 or PD-L1. The PD-L1-KO(2) mouse model was obtained by deleting the Exon 3-5 region of mouse Cd274 gene. While PD-L1-KO(Stock No.NM-KO-00104) mice have been pulled from shelves for some reasons.

Mice

Alpi/Akp3-KO

Strain Name：C57BL/6Smoc-AlpiemAkp3emSmoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-220124

The fragment consisting of mouse sequences from Alpi-exon3 up to Akp3-exon3 was deleted to generate Alpi/Akp3-KO mouse model.

Mice

Cd8a-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Cd8aem1(V5-IRES-luci-2A-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18030

A V5-IRES-luci-2A-EGFP expression cassette was inserted before the stop codon TAA of mouse Cd8a gene to establish a multi-labeled knockin model with V5, luciferase and EGFP fluorescent protein.

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