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Models

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Mice

hCD19/hCD3E

Strain Name：C57BL/6Smoc-Cd19em1(hCD19)Cd3eem1(hCD3E)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190027

This CD19 and CD3E double knockin strain is established by crossing CD19-HU and CD3E-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hTLR9/hOX40

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Tnfrsf4em3(hTNFRSF4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190024

This TLR9 and OX40 double knockin strain is established by crossing TLR9-HU and OX40-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hIL6/hIL6R

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Il6raem1(hIL6R)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190025

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hLAG3/hCTLA-4

Strain Name：B6.129S-Lag3tm1(hLAG3)Ctla4em1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190018

This LAG3 and CTLA4 double knockin strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Rag2/Il2rg-KO/hSIRPA(BALB/c,2)

Strain Name：BALB/cAnSmoc-Sirpatm(hSIRPA)Rag2em1IL2rgem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-234081

On the basis of strain hSIRPA(BALB/c,2), Rag2 and Il2rg gene exon3 and Il2rg gene exon2 were knocked out to establish Rag2 and IL2RG gene knockout mouse models in hSIRPA(BALB/c,2) background.

Mice

Rag2/IL2rg/Flt3-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Rag2em1IL2rgem1Flt3em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-234080

In the background of Rag2/IL2rg-KO (BALB/c)(NM-KO-210231), the exon3 of Flt3 gene was knocked out to establish Rag2, IL2rg and Flt3 gene knockout mouse models.

Mice

Fcgr2b/Fcgr3/Fcgr4/Fcer1g-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Fcgr2bemFcgr3emFcgr4emFcer1gem1Smoc
Strain State：Developing | Cat. NO.：NM-KO-252414

By knocking out exon1-8 of the Fcgr2b gene, exon1-5 of the Fcgr3 gene, and exon1-5 of the Fcgr4 gene, and introducing mutations into exon 1 of the Fcer1g gene, Fcgr2b, Fcgr3, Fcgr4, and Fcer1g gene knockout mouse models were established.

Mice

Mt1-Flox/Mt2-Flox

Strain Name：C57BL/6Smoc-Mt1 em1（flox）Mt2 em1（flox）Smoc
Strain State：Developing | Cat. NO.：NM-CKO-252576

The MT1-FLOX model was constructed based on Mt2-Flox (NM-CKO-226357) by inserting loxP sites on both sides of exon 2-3 of the Mt1 gene respectively. This flox mouse can be mated with tissue-specific Cre tool mice to obtain mouse models with the Mt1 gene knocked out in specific cell types or tissues.

Mice

Tet2-KO

Strain Name：B6;129S-Tet2tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00127

Exon3 of mouse Tet2 gene was replaced by frt-Pgk-Neo-polyA-frt cassette by homologous recombination.

Mice

hCD40

Strain Name：C57BL/6Smoc-Cd40em1(hCD40) Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00076

The endogenous extracellular mouse Cd40 gene was replaced by the extracellular region of human CD40 gene.

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