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Models

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Mice

B2m-KO(NMG)

Strain Name：M-NSG-B2memSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-NSG-002
Validation Data：Presence

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.

Mice

Hc-KO

Strain Name：C57BL/6Smoc-Hcem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190191
Validation Data：Presence

This Hc knockout mouse model was generated by knocking out the exon 6 region of the Hc.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069
Validation Data：Presence  |  Publications：5piece

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Cdkn2a-KO(p16-KO)

Strain Name：C57BL/6Smoc-Cdkn2aem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-240239

Cdkn2a(p16) gene knockout mouse model was established by knockout exon1 of Cdkn2a-p16INK4a transcript (Cdkn2a-201 transcript).

Mice

Fcgr1-KO

Strain Name：C57BL/6Smoc-Fcgr1em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18033

The Fcgr1 knockout mouse model was obtained by knocking out all coding regions of mouse Fcgr1 gene.

Mice

hB7H4

Strain Name：C57BL/6Smoc-Vtcn1tm1(hVTCN1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190004

This VTCN1 humanized mouse model was established by replacing the mouse Vtcn1 gene with the human VTCN1. While hB7H4(2)(Stock No.NM-HU-190075) mice function similarly to hB7H4 mice,for more detailed information please contact our technical advisor.

Mice

hTLR9

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18016
Validation Data：Presence

This TLR9 humanized mouse model was established by replacing the mouse Tlr9 gene exon2 with the human TLR9 corresponding sequence by homologous recombination.

Mice

Drd2-KO

Strain Name：C57BL/6Smoc-Drd2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190265

This Drd2 knockout mouse model was generated by knocking out the exon 3 region of the Drd2.

Mice

hAPOE2

Strain Name：C57BL/6Smoc-Apoetm4(hAPOE2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190013
Validation Data：Presence

This APOE2 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE2 corresponding sequence by homologous recombination.

Mice

Alpl-KO

Strain Name：C57BL/6Smoc-Alpltm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18058
Validation Data：Presence

This Alpl knockout mouse model was obtained by knocking out the exon 3-4 region of the Alpl gene.

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