Welcome to Advanced Search

Models

About 609 results
Mice

Cdh5-2A-tdTomato-IRES-CreERT2

Strain Name：C57BL/6Smoc-Cdh5em1(2A-tdTomato-IRES-CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-242750

This strain was donated by Yue Xu from Zhongshan Ophthalmic Center, Sun Yat-sen University. When publishing, it should be acknowledged as follows: Cdh5-2A-tdTomato-IRES-CreERT2 mice (Cat. NO. NM-KI-242750) were purchased from Shanghai Model Organisms Center, Inc. (SMOC).This strain was donated to SMOC by Yue Xu from Zhongshan Ophthalmic Center, Sun Yat-sen University.

Mice

Vsir-KO(2)

Strain Name：C57BL/6Smoc-Vsirem5Smoc
Strain State：Developing | Cat. NO.：NM-KO-200649

Vsir-KO(2) mice(Stock No.NM-KO-200649）carry a knockout allele derived from the targeted deletion of exon 2. While Vsir-KO mice (Stock No.NM-KO-18047) carrying the exon 2-3 deletion.

Mice

hIL18R1(2)/hIL18RAP

Strain Name：C57BL/6Smoc-Il18r1tm2(hIL18R1)Il18raptm2(hIL18RAP)Smoc
Strain State：Developing | Cat. NO.：NM-HU-252777

The model was constructed based on hIL18R1(2)NM-HU-252779,the endogenous mouse Il18rap gene was replaced by human IL18RAP gene.

Mice

B2m-KO(NMG)

Strain Name：M-NSG-B2memSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-NSG-002
Validation Data：Presence

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.

Mice

Hc-KO

Strain Name：C57BL/6Smoc-Hcem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190191
Validation Data：Presence

This Hc knockout mouse model was generated by knocking out the exon 6 region of the Hc.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069
Validation Data：Presence  |  Publications：5piece

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

hCD20/hBAFF(Balb/c)

Strain Name：Balb/c-Ms4a1tm1(hMS4A1)Igs2tm1(pAlb-hTNFSF13B-3'UTR var-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-252775

The model was constructed based on NM-HU-220638 hCD20(BALB/c), pAlb-hTNFSF13B-3'UTR var-polyA expression cassette was knocked into the the Igs2 locus.

Mice

IL1B-Luc-Tg

Strain Name：B6.Cg-Tg(IL1B-Luc)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-TG-00001
Validation Data：Presence  |  Publications：1piece

The transgenic mice model could be used to study transcriptional regulation of the IL-1βgene expression in the inflammatory process and evaluation the effect of anti-inflammatory drug in vivo.

Mice

R26-pAPOE-hCYP3A4(FVB)

Strain Name：FVB-Gt(ROSA)26Sortm1(pAPOE-CYP3A4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18032

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.

Mice

Mt1-Flox/Mt2-Flox

Strain Name：C57BL/6Smoc-Mt1 em1（flox）Mt2 em1（flox）Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-252576

The MT1-FLOX model was constructed based on Mt2-Flox (NM-CKO-226357) by inserting loxP sites on both sides of exon 2-3 of the Mt1 gene respectively. This flox mouse can be mated with tissue-specific Cre tool mice to obtain mouse models with the Mt1 gene knocked out in specific cell types or tissues.

Email Back to top