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Models

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Mice

Ccdc47-Flox

Strain Name：C57BL/6Smoc-Ccdc47tm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2101137

These mice carry loxP sites flanking exon 5-9 of Ccdc47 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ccdc47 gene.

Mice

R26-CAG-LSL-OVA-Luc-IRES-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpolyA-CAG-FRT-loxp-stop-loxp-OVA-IRES-Luciferase-2A-tdTomato-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200230

These mice harbor a SA-FRT-2xpolyA-CAG-FRT-loxp-stop-loxp-OVA-IRES-Luciferase-2A-tdTomato-WPRE-polyA cassette in the Rosa26 locus generated by homologous recombination.

Mice

R26-CAG-Metrnl

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-Metrnl-WPRE-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-225077

CAG-Metrnl-WPRE-pA expression cassette was knocked into the the Rosa26 locus.

Mice

R26-CAG-LSL-Armc12-IRES-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-Armc12-IRES-tdTomato-Wpre-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200290

A CAG-LSL-Armc12-IRES-tdTomato-Wpre-pA expression cassette was knocked into the Rosa26 locus via CRISPR/Cas9 mediated recombination.

Mice

R26-CAG-LSL-Il33-IRES-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-Il33-IRES-tdTomato -WPRE-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200053

These mice harbor a SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-Il33-IRES-tdTomato -WPRE-polyA cassette in the Rosa26 locus generated by homologous recombination.

Mice

hMASP3

Strain Name：C57BL/6Smoc-Masp1tm1(hMASP3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-231491

The MASP1 gene encodes the MASP3 protein through alternative splicing. This strain was a knock-in model generated by homologous recombination with an hMASP3 cassette at Masp1 gene locus.

Mice

hOX40/hCTLA-4

Strain Name：C57BL/6Smoc-Tnfrsf4tm3(hTNFRSF4)Ctla4tm1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00105

These mice are OX40 and CTLA4 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hCD19/hCD3E

Strain Name：C57BL/6Smoc-Cd19tm1(hCD19)Cd3etm1(hCD3E)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190027
Validation Data：Presence

This CD19 and CD3E double knockin strain is established by crossing CD19-HU and CD3E-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hTLR9/hOX40

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Tnfrsf4tm3(hTNFRSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190024

This TLR9 and OX40 double knockin strain is established by crossing TLR9-HU and OX40-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hIL6/hIL6R

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Il6ratm1(hIL6R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190025
Validation Data：Presence

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

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