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Mice

Wnt1-Dre

Strain Name：C57BL/6Smoc-Wnt1em1(Dre-Wpre-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200176

A Dre-Wpre-polyA expression cassette was knocked into the Wnt1 gene start codon site. Wnt1 gene is involved in stem cell poliferation in multiple systems, including the hematopoietic system and the embryonic nervous system. This strain may be useful for studying central nervous system development. When crossed with a strain carrying a gene flanked by rox sites, the flanked gene will be removed in cells expressing dre.

Mice

hPD-1/hSTING

Strain Name：C57BL/6Smoc-Tmem173tm1(hTMem173)Pdcd1em1(hPDCD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000104

hPD-1(NM-HU-00015) was crossed with hSTING(NM-HU-190036) to generate hPD-1/hSTING.

Mice

Itgax-2A-DreERT2

Strain Name：C57BL/6Smoc-Itgaxem1(2A-DreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190032

A 2A-DreERT2 expression cassette was knocked into the Itgax gene stop codon site.

Mice

hCRLF2

Strain Name：C57BL/6Smoc-Crlf2tm1(hCRLF2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210028

The endogenous mice Crlf2 gene was completely or partially replaced by human CRLF2 gene via ESC targeting.

Mice

Avp-IRES-Cre

Strain Name：C57BL/6Smoc-Avpem1(IRES2-Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200142

A IRES2-Cre-WPRE-polyA expression cassette was knocked into the Avp gene stop codon site. Avp encodes arginine vasopressin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying hypertension.

Mice

Ctsk-2A-CreERT2

Strain Name：C57BL/6Smoc-Ctskem1(2A-CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200067

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Ctsk gene stop codon site.

Mice

Gli1-CreERT2

Strain Name：C57BL/6Smoc-Gli1em1(CreERT2-Wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200073

A CreERT2-Wpre-polyA expression cassette was knocked into the Gli1 gene start codon site. Gli1 encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. When these Gli1-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Gli1 expressing cells; making them useful for studying axis patterning, proliferation, and cell fate specification of Hedgehog responding cells at different stages of embryogenesis.

Mice

Scgb1a1-IRES-Cre

Strain Name：C57BL/6Smoc-Scgb1a1em1(IRES-Cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210120

IRES-Cre expression cassette was knocked into the Scgb1a1 gene.

Mice

H11-CAG-LSL-Mycn-IRES-EGFP

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-HAtag-Mycn-IRES-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190084

These mice harbor a CAG-LSL-HA tag-Mycn-IRES-EGFP cassette in the lgs2 locus generated by homologous recombination.

Mice

Isl1-Cre

Strain Name：C57BL/6Smoc-Isl1em1(iCre-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200126

A iCre-WPRE-pA expression cassette was knocked into the Isl1 gene start codon site.

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