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Models

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Mice

Cd68-IRES-Cre

Strain Name：C57BL/6Smoc-Cd68em1(IRES-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200161

A IRES-Cre expression cassette was knocked into the Cd68 gene stop codon site.

Mice

Bmi1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Bmi1em1(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200095

A IRES-CreERT2 expression cassette was knocked into the Bmi1 gene stop codon site.

Mice

Ascl1-CreERT2

Strain Name：C57BL/6Smoc-Ascl1em1(CreERT2-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200207

A CreERT2-Wpre-pA expression cassette was knocked into the Ascl1 gene start codon site.

Mice

Gad2-IRES-Cre

Strain Name：C57BL/6Smoc-Gad2em1(IRES-iCre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200078

A IRES-iCre-pA expression cassette was knocked into the Gad2 gene stop codon site.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

R26-CAG-LSL-Foxk1-2A-tdtomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-Foxk1-2A-tdtomato-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200314

A CAG-LSL-Foxk1-2A-tdtomato-WPRE-pA expression cassette was knocked into the Rosa26 locus.

Mice

Ifnb-HiBiT

Strain Name：C57BL/6Smoc-Ifnbem1(HiBiT-tag)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200329

HiBiT was knocked into the stop coden of interferon beta 1 gene via CRISPR/Cas9 mediated recombination.

Mice

Cd19-2A-DreERT2

Strain Name：C57BL/6Smoc-Cd19em(2A-DreERT2-Wpre-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-215084

2A-DreERT2-Wpre-pA expression cassette was knocked into the Cd19 gene .

Mice

Bhlha15-CreERT2

Strain Name：C57BL/6Smoc-Bhlha15em1(CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200080

The coding region of Bhlha15 gene was replaced by a CreERT2 expression cassette.Besides,a kozak-CreERT2-WPRE-polyA expression cassette were knock into the Bhlha15 gene start codon site to generate Bhlha15-CreERT2(2)(Stock No. NM-KI-200158) mice. Bhlha15(basic helix-loop-helix family member a15) is also known as Mist1. The gene product is involved in controlling exocrine secretion from the pancreas, small intestine and stomach. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Bhlha15.

Mice

Il11-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il11em1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00036

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il11.

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