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Models

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Mice

hLAG3/hCTLA-4

Strain Name：B6.129S-Lag3tm1(hLAG3)Ctla4em1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190018

This LAG3 and CTLA4 double knockin strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hCTLA-4/4-1BB

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4) Tnfrsf9em1(hTNFRSF9) /Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18020

This CTLA4 and 4-1BB double knockin strain is established by crossing CTLA4-HU and 4-1BB-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Tnfrsf1a/Tnfrsf1b-KO

Strain Name：C57BL/6Smoc-Tnfrsf1aem1Smoc Tnfrsf1aem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18036

This strain is also called p55/p75-KO. The Tnfrsf1a and Tnfrsf1b double knockout mouse models were obtained by knocking out both exon 2-5 region of mouse Tnfrsf1a gene and exon2 of mouse Tnfrsf1b gene. Tnfrsf1a and Tnfrsf1b deletion (p55 and p75 deficiency) homozygous mice are viable and fertile, and these homozygous mice fail to bind TNF (tumor necrosis factor).

Mice

Ehd4-KO

Strain Name：C57BL/6Smoc-Ehd4em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190269

This Ehd4 knockout mouse model was generated by knocking out the exon 3 region of the Ehd4.

Mice

Gpr152-KO

Strain Name：C57BL/6Smoc-Gpr152em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190284

This Gpr152 knockout mouse model was generated by knocking out the exon 2 region of the Gpr152.

Mice

Socs3-KO

Strain Name：C57BL/6Smoc-Socs3em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190150

This Socs3 knockout mouse model was generated by knocking out the exon 2 region of the Socs3.

Mice

Rag2-KO/hVEGFR2

Strain Name：C57BL/6Smoc-Kdrtm2(hKDR)Rag2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200280

The Rag2 gene of NM-HU-00098 was knock out.

Mice

B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1SmocB2mem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-002

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.

Mice

1300017j02Rik-KO

Strain Name：C57BL/6Smoc-1300017j02Rikem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190231

This 1300017j02Rik knockout mouse model was generated by knocking out the exon2-12 region of the 1300017j02Rik.

Mice

Clec12a-KO

Strain Name：C57BL/6Smoc-Clec12aem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190222

This Clec12a knockout mouse model was generated by knocking out the exon2-4 region of the Clec12a.

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