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Models

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Mice

R26-CAG-LSL-CAMK2G

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem(CAG-loxP-STOP-loxP-CAMK2G-WPRE-pA)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-220326

CAG-loxP-STOP-loxP-CAMK2G-WPRE-pA expression cassette was knocked into the the Rosa26 locus.

Mice

R26-CAG-Metrnl

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-Metrnl-WPRE-pA)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-225077

CAG-Metrnl-WPRE-pA expression cassette was knocked into the the Rosa26 locus.

Mice

R26-CAG-LSL-Armc12-IRES-tdTomato

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-Armc12-IRES-tdTomato-Wpre-pA)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-200290

A CAG-LSL-Armc12-IRES-tdTomato-Wpre-pA expression cassette was knocked into the Rosa26 locus via CRISPR/Cas9 mediated recombination.

Mice

hMASP3

Strain Name:C57BL/6Smoc-Masp1tm1(hMASP3)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-231491

The MASP1 gene encodes the MASP3 protein through alternative splicing. This strain was a knock-in model generated by homologous recombination with an hMASP3 cassette at Masp1 gene locus.

Mice

Trpv2-Flox

Strain Name:B6;129S-Trpv2tm1(flox)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-CKO-00023

Mice homozygous for a knock-out allele exhibit impaired macrophage migration, binding, and phagocytosis with increased susceptiblity and mortality following bacterial infection.

Mice

Mir22-KO(FVB)

Strain Name:FVB-Mir22tmSmoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KO-210396

These mice carry a knock-out mutation of Mir22 (microRNA 22)

Mice

hOX40/hCTLA-4

Strain Name:C57BL/6Smoc-Tnfrsf4tm3(hTNFRSF4)Ctla4tm1(hCTLA4)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-00105

These mice are OX40 and CTLA4 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Gabra1-F324L

Strain Name:C57BL/6Smoc-Gabra1em(F324L)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-220099

These mice carry a F324L mutation of Gabra1 gene.

Mice

Ptpn2-Y278C

Strain Name:C57BL/6Smoc-Ptpn2tm(Y278C)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-225038

These mice carry a Y278C mutation of Ptpn2 gene.

Mice

hCD19/hCD3E

Strain Name:C57BL/6Smoc-Cd19tm1(hCD19)Cd3etm1(hCD3E)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190027
Validation Data:Presence

This CD19 and CD3E double knockin strain is established by crossing CD19-HU and CD3E-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

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