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Models

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Mice

R26-CAG-LSL-hEGFR*L858R-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-EGFR (L858R)-IRES-Luciferase-2A-tdTomato)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190069

These mice harbor a CAG-LSL-EGFR(L858R)-IRES-Luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.

Mice

R26-CAG-LSL-hFGFR2*K659N-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-FGFR2(K659N)-IRES-Luciferase-2A-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190078

These mice harbor a CAG-LSL-FGFR2(K659N)-IRES-Luciferase-2A-EGFP cassette in the Rosa26 locus generated by homologous recombination.

Mice

R26-CAG-LSL-hTPM3-NTRK1-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem(SA-polyA-CAG-LSL-TPM3-NTRK1-IRES-luc-2A-tdTomato-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190098

These mice harbor a SA-polyA-CAG-LSL-TPM3-NTRK1-IRES-luc-2A-tdTomato-WPRE-polyA cassette in the Rosa26 locus generated by homologous recombination.

Mice

R26-CAG-LNL-ddCas9

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LNL-ddCas9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00063

These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven ddCas9. The targeted mutation was inserted into the Gt(ROSA)26Sor locus.

Mice

R26-CAG-LSL-hEGFR*T790M-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-EGFR (T790M) -IRES-Luciferase-2A-tdTomato)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190070

These mice harbor a CAG-LSL-EGFR(T790M)-IRES-Luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.

Mice

R26-LSL-Notch1C-IRES-nEGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-LSL-Notch1C-IRES-nEGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200036

These mice harbor a SA-LSL-Notch1C-IRES-nEGFP cassette in the Rosa26 locus generated by homologous recombination.Notch1C (mouse Notch1 ,amino acids 1749–2293)

Mice

R26-CAG-LSL-hBCR/ABL

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-loxp-STOP-loxp-BCR-ABL-IRES-Luciferase-2A-tdTomato-WPRE-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190127

These mice harbor a CAG-LSL-BCR-ABL-IRES-Luciferase-2A-tdTomato-WPRE-PA cassette in the Rosa26 locus generated by homologous recombination.

Mice

R26-CAG-Cas9

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-Cas9)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00120

These mice were established by crossing R26-(CAG-LSL-Cas9) and EIIA mice together.

Mice

R26-LSL-SmoM2W539L-IRES-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-loxp-stop-loxp-SmoM2(W539L)-IRES-tdTomato-WPRE-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200035

These mice harbor a SA-loxp-stop-loxp-SmoM2(W539L)-IRES-tdTomato-WPRE-polyA cassette in the Rosa26 locus generated by homologous recombination. W539L point mutation of the mouse gene (SmoM2), which corresponds to the W535L mutation in the human sequence.

Mice

R26-CAG-LNL-Cas9-IRES-Luc

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LNL-Cas9-IRES-Luciferase-pA)
Strain State：Repository Live | Cat. NO.：NM-KI-18002

These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Cas9 gene followed by IRES-Luciferase coexpression cassette. The targeted mutation was inserted into the Rosa26 locus by homologous recombination.

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