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Models

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Mice

Foxn1-IRES-Cre

Strain Name：C57BL/6Smoc-Foxn1em1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200106

A IRES-iCre expression cassette was knocked into the Foxn1 gene stop codon site. The protein encoded by Foxn1 (forkhead box N1) gene is part of the forkhead family or transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in thymic epithelial cell and keratinocytes.

Mice

Txlna-Luc-EGFP

Strain Name：C57BL/6Smoc-Txlnaem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00026

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Txlna.

Mice

Shh-CreERT2

Strain Name：C57BL/6Smoc-Shhem1(CreERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200145

A CreERT2-WPRE-polyA expression cassette was knocked into the Shh gene start codon site.

Mice

Foxp3-IRES-tdTomato-2A-CreERT2

Strain Name：C57BL/6Smoc-Foxp3em4(IRES-tdTomato-2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190120

A IRES-tdTomato-2A-CreERT2 expression cassette was knocked into the Foxp3 gene stop codon site.

Mice

Wnt1-Dre

Strain Name：C57BL/6Smoc-Wnt1em1(Dre-Wpre-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200176

A Dre-Wpre-polyA expression cassette was knocked into the Wnt1 gene start codon site. Wnt1 gene is involved in stem cell poliferation in multiple systems, including the hematopoietic system and the embryonic nervous system. This strain may be useful for studying central nervous system development. When crossed with a strain carrying a gene flanked by rox sites, the flanked gene will be removed in cells expressing dre.

Mice

Foxp3-V5-AviTag-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Foxp3em1(V5-AviTag-IRES-luci-2A-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18034

A V5-AviTag-IRES-luci-2A-tdTomato expression cassette was inserted before the stop codon TGA of mouse Foxp3 gene to establish a multi-labeled knockin model with V5, Avi, luciferase and tdTomato fluorescent protein.

Mice

hPD-1/hSTING

Strain Name：C57BL/6Smoc-Tmem173tm1(hTMem173)Pdcd1em1(hPDCD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000104

hPD-1(NM-HU-00015) was crossed with hSTING(NM-HU-190036) to generate hPD-1/hSTING.

Mice

Itgax-2A-DreERT2

Strain Name：C57BL/6Smoc-Itgaxem1(2A-DreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190032

A 2A-DreERT2 expression cassette was knocked into the Itgax gene stop codon site.

Mice

Avp-IRES-Cre

Strain Name：C57BL/6Smoc-Avpem1(IRES2-Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200142

A IRES2-Cre-WPRE-polyA expression cassette was knocked into the Avp gene stop codon site. Avp encodes arginine vasopressin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying hypertension.

Mice

hIL17A/hIL17F

Strain Name：C57BL/6Smoc-Il17atm1(hIL17A)Il17fem2(hIL17F)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200281

The endogenous mouse Il17a&Il17f genes were replaced by human IL17A&IL17F gene.

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