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Models

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Mice

Ntrk2-CreERT2

Strain Name：C57BL/6Smoc-Ntrk2em1(CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200146

A CreERT2-WPRE-polyA expression cassette was knocked into the Ntrk2 gene start codon site. Ntrk2 encodes the tropomyosin receptor kinase B (TrkB), transmission through which neurotrophic factors modify differentiation, plasticity, and synaptic transmission. When these Ntrk2-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Ntrk2 expressing cells.

Mice

Slc6a11-CreERT2

Strain Name：C57BL/6Smoc-Slc6a11em1(CreERT2-polyA(SV40)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200130

A CreERT2-polyA expression cassette was knocked into the Slc6a11 gene start codon site. Slc6a11 encodes GAT3 (Gabt4), a sodium-dependent transporter that uptakes the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which ends the GABA neurotransmission. When Slc6a11-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLC6A11positive cells. Defects in Slc6a11 may result in epilepsy or behavioral and intellectual defects.

Mice

Atp4b-IRES-CreERT2

Strain Name：C57BL/6Smoc-Atp4bem1(IRES-CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210118

An IRES-CreERT2-WPRE-pA expression cassette was knocked into the Atp4b gene stop codon site. Besides, An IRES-CreERT2 expression cassette were knock into the Bhlha15 gene stop codon site to generate Atp4b-IRES-CreERT2(2)(Stock No. NM-KI-210119) mice.

Mice

R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(Gut-CYP3A4-IRES-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18033

Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.

Mice

Acta2-CreERT2

Strain Name：C57BL/6Smoc-Acta2em1(CreERT2-Wpre-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200074

A CreERT2-Wpre-polyA expression cassette was knocked into the Acta2 gene start codon site.

Mice

Th-2A-tdTomato

Strain Name：C57BL/6Smoc-Them1(2A-tdTomato)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210124

2A-tdTomato expression cassette was knocked into the Th gene.

Mice

Cd68-2A-Cre

Strain Name：C57BL/6Smoc-Cd68em5(2A-Cre-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200192

This Cd68-Cre tool mouse model was established by inserting a 2A-Cre-WPRE-polyA co-expression cassette into the stop codon of Cd68 gene .

Mice

Anxa10-2A-CreERT2

Strain Name：C57BL/6Smoc-Anxa10em1(2A-CreERT2-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200312

2A-CreERT2-Wpre-pA expression cassette was knocked into the Anxa10 gene stop codon site.

Mice

R26-CAG-LSL-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-Luciferase-2A-EGFP-wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190095

A CAG-LSL-Luciferase-2A-EGFP-wpre-polyA expression cassette was inserted at the Rosa26 locus site.

Mice

Scgb1a1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Scgb1a1em1(IRES-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200129

A IRES-CreERT2 expression cassette was knocked into the Scgb1a1 gene stop codon site.

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