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Models

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Mice

R26-CAG-LSL-Tlr4

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-Tlr4-WPRE-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190112

These mice harbor a CAG-LSL-Tlr4-WPRE-polyA cassette in the Rosa26 locus generated by homologous recombination.

Mice

hPD-1/hTLR9

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Tlr9 tm1(hTLR9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190023

hPD-1(NM-HU-00015) was crossed with hTLR9(NM-HU-18016) to generate hPD-1/hTLR9.

Mice

1300017j02Rik-KO

Strain Name：C57BL/6Smoc-1300017j02Rikem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190231

This 1300017j02Rik knockout mouse model was generated by knocking out the exon2-12 region of the 1300017j02Rik.

Mice

hPD-1/hCD40

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd40em1(hCD40)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190017

hPD-1(NM-HU-00015) was crossed with hCD40(NM-HU-00076) to generate hPD-1/hCD40.

Mice

Il33-KO(2)

Strain Name：C57BL/6Smoc-Il33em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190436

Il33-KO(2) mice(Stock No.NM-KO-190436) carry a knockout allele derived from the targeted deletion of exon 3-7. While Il33-KO mice(Stock No.NM-KO-00099) have been pulled from shelves for some reasons and Il33-KO(3) mice(Stock No.NM-KO-210206) carrying the exon 2 deletion.

Mice

hLAG3/hCTLA-4

Strain Name：B6.129S-Lag3tm1(hLAG3)Ctla4em1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190018

This LAG3 and CTLA4 double knockin strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hKLRK1

Strain Name：C57BL/6Smoc-Klrk1em1(hKLRK1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190005

The endogenous mouse Klrk1 gene was replaced by human KLRK1 gene.

Mice

MHC Class II(I-A/I-E)-KO(Nod-Scid)

Strain Name：NOD-PrkdcscidH2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-psem1Smoc
Strain State：Developing | Cat. NO.：NM-KO-18057

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the Nod-Scid genetic background and lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

Il4-KO

Strain Name：C57BL/6Smoc-Il4em2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190503

Exon 2-4 of Il4 gene was deleted to generate Il4 knockout mice.

Mice

H2-Eb1-KO

Strain Name：C57BL/6Smoc-H2-Eb1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-191128

Exon 2-5 of H2-Eb1 gene was deleted to generate H2-Eb1 knockout mice.

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