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Models

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Mice

H2/H2-K1-KO(NMG)

Strain Name：NOD-PrkdcscidIl2rgem1h2em2H2-K1em2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-NSG-006

Exon 2 of H2;H2-K1 gene was deleted to generate H2;H2-K1 knockout mice.

Mice

hPD-1/hPD-L1/hLAG3

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Lag3em1(hLAG3)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190028

hPD-1(NM-HU-00015),hPD-L1(NM-HU-00062) were crossed with hLAG3(NM-HU-00049) to generate hPD-1/hPD-L1/hLAG3.

Mice

hPD-1/hCD40

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd40em1(hCD40)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190017

hPD-1(NM-HU-00015) was crossed with hCD40(NM-HU-00076) to generate hPD-1/hCD40.

Mice

MHC Class II(I-A/I-E)-KO(Nod-Scid)

Strain Name：NOD-PrkdcscidH2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-psem1Smoc
Strain State：Developing | Cat. NO.：NM-KO-18057

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the Nod-Scid genetic background and lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

hKLRK1

Strain Name：C57BL/6Smoc-Klrk1em1(hKLRK1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190005

The endogenous mouse Klrk1 gene was replaced by human KLRK1 gene.

Mice

Il33-KO(2)

Strain Name：C57BL/6Smoc-Il33em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190436

Il33-KO(2) mice(Stock No.NM-KO-190436) carry a knockout allele derived from the targeted deletion of exon 3-7. While Il33-KO mice(Stock No.NM-KO-00099) have been pulled from shelves for some reasons and Il33-KO(3) mice(Stock No.NM-KO-210206) carrying the exon 2 deletion.

Mice

MHC ClassII(I-A/I-E)-KO(NMG)

Strain Name：NOD-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1Smoc
Strain State：Developing | Cat. NO.：NM-NSG-003

All sequences from the upstream of  mouse H2-Ab1 gene exon 2  to the upstream of the H2-Ea-ps gene  exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.  These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

R26-hCD46-IRES-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-hCD46-IRES-tdTomato-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190087

These mice harbor a SA-human CD46-IRES-tdTomato-polyA cassette in the Rosa26 locus generated by homologous recombination.

Mice

Il9-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il9em1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00023

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il9.

Mice

Fas-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Fasem2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-191206

Exon 2 of Fas gene was deleted to generate Fas knockout mice.

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