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Models

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Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Fcgrtem1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

Rag2/Il2rg-KO/hSIRPA(BALB/c,2)

Strain Name：BALB/cAnSmoc-Sirpatm(hSIRPA)Rag2em1IL2rgem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-234081

On the basis of strain hSIRPA(BALB/c,2), Rag2 and Il2rg gene exon3 and Il2rg gene exon2 were knocked out to establish Rag2 and IL2RG gene knockout mouse models in hSIRPA(BALB/c,2) background.

Mice

Rag2/IL2rg/Flt3-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Rag2em1IL2rgem1Flt3em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-234080

In the background of Rag2/IL2rg-KO (BALB/c)(NM-KO-210231), the exon3 of Flt3 gene was knocked out to establish Rag2, IL2rg and Flt3 gene knockout mouse models.

Mice

Fcgr2b/Fcgr3/Fcgr4/Fcer1g-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Fcgr2bemFcgr3emFcgr4emFcer1gem1Smoc
Strain State：Developing | Cat. NO.：NM-KO-252414

By knocking out exon1-8 of the Fcgr2b gene, exon1-5 of the Fcgr3 gene, and exon1-5 of the Fcgr4 gene, and introducing mutations into exon 1 of the Fcer1g gene, Fcgr2b, Fcgr3, Fcgr4, and Fcer1g gene knockout mouse models were established.

Mice

R26-pAPOE-hCYP3A4(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(pAPOE-CYP3A4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18032

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.

Mice

R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(Gut-CYP3A4-IRES-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18033

Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.

Mice

Dux-KO

Strain Name：C57BL/6Smoc-Duxem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-242098

The Gm19459 gene, Gm4981 gene, Duxf3 gene, Gm10807 gene and AW822073 gene were deleted to generate Dux gene cluster knockout mouse.

Mice

Foxl1-2A-CreERT2

Strain Name：C57BL/6Smoc-Foxl1em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00135

A 2A-CreERT2 coexpression cassette is inserted before the stop codon of mouse Foxl1 gene via homologous recombination to establish a Foxl1-CreERT2 recombinase tool stain. This strain can be used to knockout target gene inFoxl1+ cells after tamoxifen treatment when crossed with flox mice.

Mice

Sox9-IRES-Flp

Strain Name：B6;129S-Sox9tm1(IRES-Flp)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00131

An IRES-Flp-polyA coexpression cassette is inserted at 3' terminal of mouse Sox9 gene via homologous recombination to establish a Sox9-Flp recombinase tool stain. This strain can be used to knockout target gene in Sox9+ cells when crossed with mice which carry frt sites flanking target gene.

Mice

Tie1-2A-Cre

Strain Name：C57BL/6Smoc-Tie1em1(2A-Cre)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18023

A 2A-Cre coexpression cassette is inserted befor the stop codon of mouse Tie1 gene via homologous recombination to establish a tamoxifen inducible Tie1-Cre tool stain. This strain can be used to knockout target gene in Tie1+ cells when crossed with mice which carry loxp sites flanking target gene.

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