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Models

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Mice

Zic2-KO

Strain Name：C57BL/6Smoc-Zic2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00082

This Zic2 gene knockout mouse model is generated by TALEN technology.

Mice

F9-KO

Strain Name：C57BL/6Smoc-F9em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18046

The F9 gene is located on the X chromosome. In this F9 knockout mouse model, gRNAs were designed targeting Exon8 of F9 gene via CRISPR gene editing technology. Loss of F9 caused coagulopathy in mice. Mice that are homozygous for F9 knockout are viable, fertile and normal in size. Normal fighting in the cage may cause bleeding or even death due to massive internal hemorrhaging. After the tail cutting, wounds must be cauterized to prevent homozygous knockout mice from blood loss and death. This strain is a powerful model for studying coagulopathy, gene therapy methods and function of factor IX mutations. F9-KO mice (Stock No.NM-KO-18046）carry a knockout allele derived from the targeted deletion of exon 8. While F9-KO(2) mice (Stock No.NM-KO-200607) carrying the exon 1-8 deletion.

Mice

Resp18-KO

Strain Name：B6;129S-Resp18tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00022

These Resp18 knockout mice were established technology and crossed with FLP transgenic mice to delete PGK-Neo gene.

Mice

Atp7B-KO

Strain Name：C57BL/6Smoc-Atp7Bem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-2105045

Using CRISPR/Cas9 technology, exon 2 of Atp7B gene was deleted to generate Atp7B knockout mice.

Mice

Cd74-KO

Strain Name：C57BL/6Smoc-Cd74em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190772

Using CRISPR/Cas9 technology,exon 2 of Cd74 gene was deleted to generate Cd74 knockout mice.

Mice

Selplg-KO(2)

Strain Name：C57BL/6Smoc-Selplgem2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200472

Using CRISPR/Cas9 technology, exon 2 of Selplg gene was deleted to generate Selplg knockout mice.

Mice

Esr1-KO(3)

Strain Name：C57BL/6Smoc-Esr1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-210243

Using CRISPR/Cas9 technology, exon 4 of Esr1 gene was deleted to generate Esr1 knockout mice

Mice

Tacstd2-KO(2)

Strain Name：C57BL/6Smoc-Tacstd2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200516

Using CRISPR/Cas9 technology, exon 1 of Tacstd2 gene was deleted to generate Tacstd2 knockout mice.

Mice

Txnip-KO(2)

Strain Name：C57BL/6Smoc-Txnipem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190894

Using CRISPR/Cas9 technology,exon 2 of Txnip gene was deleted to generate Txnip knockout mice.

Mice

Tmprss2-KO(2)

Strain Name：C57BL/6Smoc-Tmprss2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200534

Using CRISPR/Cas9 technology, exon 3 of Tmprss2 gene was deleted to generate Tmprss2 knockout mice.

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