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Models

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Mice

Ccl4-KO

Strain Name：C57BL/6Smoc-Ccl4em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190016

This Ccl4 knockout mouse model was generated by knocking out the exon 2 region of the Ccl4 .

Mice

Fam220a-KO

Strain Name：C57BL/6Smoc-Fam220aem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190273

This Fam220a knockout mouse model was generated by knocking out the exon 2 region of the Fam220a.

Mice

Tlr7-KO

Strain Name：C57BL/6Smoc-Tlr7em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190166

This Tlr7 knockout mouse model was generated by knocking out the exon 3 region of the Tlr7 .

Mice

B6 DIO

Strain Name：C57BL/6Smoc DIO
Strain State：Repository Live | Cat. NO.：SM-021

Diet-induced obesity (DIO) models are similar to human obesity, can effectively reflect the pathogenesis of human obesity, and are useful for studying metabolic diseases such as obesity, diabetes, and fatty liver disease.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105
Validation Data：Presence

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

hAPOE4

Strain Name：C57BL/6Smoc-Apoetm2(hAPOE4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190002
Validation Data：Presence

This APOE4 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE4 corresponding sequence by homologous recombination.

Mice

hAPOE3

Strain Name：C57BL/6Smoc-Apoetm3(hAPOE3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190003
Validation Data：Presence

This APOE3 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE3 corresponding sequence by homologous recombination.

Mice

Snca-KO

Strain Name：C57BL/6Smoc-Sncaem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190380

This Snca knockout mouse model was generated by knocking out the exon4 region of the Snca.

Mice

Enpp1-KO

Strain Name：C57BL/6Smoc-Enpp1em2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200618
Validation Data：Presence

Exon 2 of Enpp1 gene was deleted to generate Enpp1 knockout mice.

Mice

G6pc-Flox

Strain Name：C57BL/6Smoc-G6pcem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200053

These mice carry loxP sites flanking exon 3 of G6pc gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of G6pc gene.

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