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Models

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Mice

Foxn1-IRES-Cre

Strain Name：C57BL/6Smoc-Foxn1em1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200106
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Foxn1 gene stop codon site. The protein encoded by Foxn1 (forkhead box N1) gene is part of the forkhead family or transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in thymic epithelial cell and keratinocytes.

Mice

BALB/c

Strain Name：BALB/cAnSmoc
Strain State：Repository Live | Cat. NO.：SM-003

BALB/c is one of the most widely used inbred lines in biomedical research, especially in immunology and infectious disease research. The incidence of breast tumors is about 10% to 20%. There is a certain number of ovarian, adrenal, pulmonary tumors, and leukemia that occurs. Lung cancer occurs in 26% of female mice and 29% of male mice. The incidence of leukemia is 12% in females and 10% in males. Blood pressure was the highest compared to other inbred mice and had spontaneous hypertension.

Mice

hB7H3

Strain Name：C57BL/6Smoc-Cd276tm2(hB7H3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00107
Validation Data：Presence

The endogenous mouse Cd276 gene was replaced by human CD276 gene.

Mice

hCD40

Strain Name：C57BL/6Smoc-Cd40tm1(hCD40) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00076
Validation Data：Presence

The endogenous extracellular mouse Cd40 gene was replaced by the extracellular region of human CD40 gene.

Mice

Braf-Flox-V600E

Strain Name：C57BL/6Smoc-Brafem1(flox-V600E)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190053

These mice carry a conditional p.V600E mutation of Braf gene.

Mice

hCTLA-4

Strain Name：C57BL/6Smoc-Ctla4tm1(hCTLA4) Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00014
Validation Data：Presence

The endogenous mouse Ctal4 gene was replaced by human CTLA4 gene. While hCTLA4(2)(Stock No.NM-HU-190038) mice function similarly to hCTLA4 mice,for more detailed information please contact our technical advisor.

Mice

hPD-1/hCTLA-4

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Ctla4tm1(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00079
Validation Data：Presence

hPD-1(NM-HU-00015) was crossed with hCTLA4(NM-HU-00014)to generate hPD-1/hCTLA4 mice

Mice

R26-CAG-LSL-hEGFR*L858R/T790M-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LSL-EGFR (L858R-T790M)-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190068

These mice harbor a CAG-LSL-EGFR (L858R-T790M)-IRES-luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.

Mice

hCD80

Strain Name：C57BL/6Smoc-Cd80tm1(hCD80) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00074
Validation Data：Presence

The endogenous mouse Cd80 gene was replaced by human CD80 gene .

Mice

hOX40(2)

Strain Name：C57BL/6Smoc-Tnfrsf4tm3(hTNFRSF4) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00078
Validation Data：Presence

The exon1-5 and partial exon6 of endogenous mouse Tnfrsf4(Ox40) gene was replaced by the corresponding region of human TNFRSF4(OX40) gene. While hOX40(Stock No.NM-HU-00041) mice function similarly to hOX40(2) mice,for more detailed information please contact our technical advisor.

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