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Myocd-Flox

Strain Name：C57BL/6Smoc-Myocd^{em1(flox)Smoc}
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Myocd gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Myocd gene.

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1^{em1(CreERT2-SV40-pA)Smoc}
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200105
Validation Data：Presence

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

4-Phenylbutyrate restored γ-aminobutyric acid uptake and reduced seizures in SLC6A1 patient variant-bearing cell and...

Model Organisms：小鼠 Product & Service：Slc6a1-S295L(NM-KI-190014) Research field：Rare disease

SMOC Launched U-HuDTMbase®, Inclusive Resource Library of Innovative Therapeutic Target-Humanized Mouse Models, to Accelerate Novel Drug Discovery

U-HuDTMbase® is composed of more than 600 therapeutic target-humanized mouse models, including multiple background strains, and has covered almost all commonly studied areas, such as oncology, metabolism, immunity, inflammation and more.

Join Our Webinar: Applications of Humanized Mouse Models in Preclinical Research

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Join GenoBioTX's webinar on July 25th to explore the latest advancements in humanized mouse models for preclinical research. Learn how these models are transforming targeted therapy development across various diseases. Featuring expert insights from Dr. Derek Reznik, discover the generation and application of humanized immune system models in oncology drug development. Don't miss this opportunity to enhance your knowledge in cutting-edge preclinical therapeutic advancements. Register now!

New Service Launch: Mouse Bone Metastasis Cancer Model and Pain-Related Behavior Assessment!

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We are excited to announce that GenoBioTX has launched a new service featuring mouse bone metastasis cancer models and pain-related behavior assessment, designed to support cancer research and pain management effectively.

News Update: GenoBioTX and Crown Bioscience Sign Global Cooperation Agreement

Liver Cancer PDX Model

PDX PDX models Patient-derived Xenografts

Patient-derived Xenografts (PDX) are advanced preclinical oncology models for drug development. It offers a far better alternative for preclinical drug evaluation as compared to the conventional cell line-derived xenograft model.

Mouse models for cancer research

Tumor bearing Mouse DEN model PDX model CDX model

Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner.

Cancer Model

research on cancer cancer model mouse models of cancer

The laboratory mouse is widely considered as a valid and affordable model organism for studying human disease. Mouse models of cancer not only enable researchers to understand the genetic basis of tumor development in complicated and dynamic physiological systems, but also serve as irreplaceable tools for developing and testing new therapies.  Shanghai Model Organisms Center offers a variety of mouse models of cancer to meet the needs of both academic and industry partners.