Welcome to Advanced Search

NOD SCID

Strain Name：NOD.Cg-Prkdc^scid/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-019
Validation Data：Presence

The strain was developed on background of non-obese diabetic (NOD) mouse with spontaneous scid mutation. NOD SCID mouse, insusceptible to diabetes, possesses reduced activity of T cells and B cells, and defect in innate immunity.NOD SCID mouse is compatible with a wider range of engraftment of cell lines in comparison with nude mouse; And it is broadly applied to construction of PDX models. However, due to a short life span(8-9 months) caused by lethal thymic lymphomas, it is unsuitable for long-term in vivo assays.

KPC

Strain Name：C57BL/6Smoc-Trp53^em4(R172H)Kras^{em4(LSL-G12D)}Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210096
Validation Data：Presence

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

Pdx1-2A-CreERT2

Strain Name：C57BL/6Smoc-Pdx1^{em1(Avi tag-2A-CreERT2)Smoc}
Strain State：Repository Live | Cat. NO.：NM-KI-18042
Validation Data：Presence

An Avi tag-2A-CreERT2 cassette was inserted at the Pdx1 gene stop codon site .

Pdx1-2A-Cre

Strain Name：C57BL/6Smoc-Pdx1^{em(2A-Cre)1Smoc}
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-225082
Validation Data：Presence

2A-Cre expression cassette was knocked into the Pdx1 gene .

Pdx1-KO

Strain Name：C57BL/6Smoc-Pdx1^em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-226397

exon 2 of Pdx1 gene was deleted to generate Pdx1 knockout mice.

Pdx1-Flox

Strain Name：C57BL/6Smoc-Pdx1^{em1(flox)Smoc}
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Pdx1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Pdx1 gene.

KPC(2)

Strain Name：C57BL/6Smoc-Trp53^{tm7(R270H-flox})Kras^{em4(LSL-G12D)}Tg(Pdx1-cre)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-220014

Trp53-LSL-R270H, Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. While KPC mice function similarly to KPC(2) mice, for more detailed information please contact our technical advisor.

News Update: GenoBioTX and Crown Bioscience Sign Global Cooperation Agreement

Liver Cancer PDX Model

PDX PDX models Patient-derived Xenografts

Patient-derived Xenografts (PDX) are advanced preclinical oncology models for drug development. It offers a far better alternative for preclinical drug evaluation as compared to the conventional cell line-derived xenograft model.

Mouse models for cancer research

Tumor bearing Mouse DEN model PDX model CDX model

Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner.