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Models

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Mice

Apoe-KO/Nos3-KO

Strain Name：C57BL/6Smoc-Apoeem5Nos3em1Smoc
Strain State：Repository Live | Cat. NO.：NM-XA-242509
Validation Data：Presence

The Apoe-KO(2)(NM-KO-190565) was crossed with Nos3-KO(NM-KO-18022) to generate Apoe-KO/Nos3-KO mice.

Mice

Trp53-Flox/Kras-LSL-G12D/Mras-KO

Strain Name：C57BL/6Smoc-Trp53tm2(flox)Krasem4(LSL-G12D)Mrasem1Smoc
Strain State：Developing | Cat. NO.：NM-XA-251978

The Trp53-Flox/Kras-LSL-G12D (NM-CKO-233079) was crossed with Mras-KO(NM-KO-241488) to generate Trp53-Flox/Kras-LSL-G12D/Mras-KO mice.

Mice

Rag1/Il2rg-KO(NOD)

Strain Name：NOD-Il2rgem1Rag1em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-232208

The Il2rg-KO(NOD)(NM-KO-232206) was crossed with Rag1-KO(NOD)(NM-KO-232207) to generate Il2rg-KO/Rag1-KO mice.

Mice

IgI/Ighj/Igkj-KO

Strain Name：C57BL/6Smoc-Iglem1Ighjem1Igkjem1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-210395
Validation Data：Presence

Igl-KO(NM-KO-191198) and Igkj-KO(NM-KO-191196) were crossed with Ighj-KO(NM-KO-191197) to generate IgI/Ighj/Igkj-KO mice.

Mice

Trpv1-KO/Trpa1-KO

Strain Name：C57BL/6Smoc-Trpv1em2Trpa1em1Smoc
Strain State：Developing | Cat. NO.：NM-XA-253700

The Trpv1-KO(2) (NM-KO-210259) was crossed with Trpa1-KO(NM-KO-190446) to generate Trpv1-KO(2)/Trpa1-KO mice.

Mice

pAlb-hLPA-3’UTR-pA-TG/Apoe-KO

Strain Name：C57BL/6Smoc-Tgtn(pAlb-hLPA-3’UTR-pA)1Apoeem5Smoc
Strain State：Repository Live | Cat. NO.：NM-XA-242591
Validation Data：Presence

The pAlb-hLPA-Tg(V2)(NM-TG-231782) was crossed with Apoe-KO(2)(NM-KO-190565) to generate pAlb-hLPA-3’UTR-pA-TG/Apoe-KO mice.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070
Validation Data：Presence

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069
Validation Data：Presence  |  Publications：5piece

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Mief2-KO

Strain Name：C57BL/6Smoc-Mief2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-201013

Exon 3 of Mief2 gene was deleted to generate Mief2 knockout mice.

Mice

Rag2-KO/hHER2

Strain Name：C57BL/6Smoc-Rag2em2Erbb2tm1(hHER2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-234873
Validation Data：Presence

The hHER2(NM-HU-200115) was crossed with Rag2-KO(NM-KO-190429) to generate Rag2-KO/hHER2 mice.

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