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Models

About 18,969 results
Mice

F9-KO

Strain Name：C57BL/6Smoc-F9em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18046

The F9 gene is located on the X chromosome. In this F9 knockout mouse model, gRNAs were designed targeting Exon8 of F9 gene via CRISPR gene editing technology. Loss of F9 caused coagulopathy in mice. Mice that are homozygous for F9 knockout are viable, fertile and normal in size. Normal fighting in the cage may cause bleeding or even death due to massive internal hemorrhaging. After the tail cutting, wounds must be cauterized to prevent homozygous knockout mice from blood loss and death. This strain is a powerful model for studying coagulopathy, gene therapy methods and function of factor IX mutations. F9-KO mice (Stock No.NM-KO-18046）carry a knockout allele derived from the targeted deletion of exon 8. While F9-KO(2) mice (Stock No.NM-KO-200607) carrying the exon 1-8 deletion.

Mice

Cd4/F8-KO

Strain Name：C57BL/6Smoc-Cd4em3F8tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-220026

Cd4-KO(2)(NM-KO-190441) was crossed with F8-KO(NM-KO-00012) to generate Cd4/F8-KO mice.

Mice

Apoe-KO/Nos3-KO

Strain Name：C57BL/6Smoc-Apoeem5Nos3em1Smoc
Strain State：Repository Live | Cat. NO.：NM-XA-242509

The Apoe-KO(2)(NM-KO-190565) was crossed with Nos3-KO(NM-KO-18022) to generate Apoe-KO/Nos3-KO mice.

Mice

Rag1/Il2rg-KO(NOD)

Strain Name：NOD-Il2rgem1Rag1em1Smoc
Strain State：Developing | Cat. NO.：NM-KO-232208

The Il2rg-KO(NOD)(NM-KO-232206) was crossed with Rag1-KO(NOD)(NM-KO-232207) to generate Il2rg-KO/Rag1-KO mice.

Mice

IgI/Ighj/Igkj-KO

Strain Name：C57BL/6Smoc-Iglem1Ighjem1Igkjem1/Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-210395

Igl-KO(NM-KO-191198) and Igkj-KO(NM-KO-191196) were crossed with Ighj-KO(NM-KO-191197) to generate IgI/Ighj/Igkj-KO mice.

Mice

pAlb-hLPA-3’UTR-pA-TG/Apoe-KO

Strain Name：C57BL/6Smoc-Tgtn(pAlb-hLPA-3’UTR-pA)1Apoeem5Smoc
Strain State：Developing | Cat. NO.：NM-XA-242591

The pAlb-hLPA-Tg(V2)(NM-TG-231782) was crossed with Apoe-KO(2)(NM-KO-190565) to generate pAlb-hLPA-3’UTR-pA-TG/Apoe-KO mice.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Tcrα/Tcrβ/Tcrg-KO

Strain Name：C57BL/6Smoc-TcrαemTcrβemTcrgemSmoc
Strain State：Repository Live | Cat. NO.：NM-XA-241756

The Tcrα-KO(2)(NM-KO-230149) was crossed with Tcrβ-KO(2)(NM-KO-230150) and Tcrg-KO(NM-KO-230157) to generate Tcrα/Tcrβ/Tcrg-KO mice.

Mice

Mief2-KO

Strain Name：C57BL/6Smoc-Mief2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-201013

Exon 3 of Mief2 gene was deleted to generate Mief2 knockout mice.

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