Models

Conditional Knockouts

In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.

Mice
Strain Name:C57BL/6Smoc-Ccr10em1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-241013
Mice
Strain Name:C57BL/6Smoc-Ccr1l1em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6Smoc-Ccr2em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-226213
Mice
Strain Name:C57BL/6Smoc-Ccr3em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-2110303
Mice
Strain Name:C57BL/6Smoc-Ccr4em(flox)/Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-220635
Mice
Strain Name:C57BL/6Smoc-Ccr5em(flox)/Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-220619
Mice
Strain Name:C57BL/6Smoc-Ccr6em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6Smoc-Ccr7em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-2112432
Mice
Strain Name:C57BL/6Smoc-Ccr8em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-231317
Mice
Strain Name:C57BL/6Smoc-Ccr9em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-234051
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