The establishment of U-GEMM (yoUr Genetically Engineered Mouse Model) repository containing 6,000+ “off-shelf” proprietary sets the stage of entry into new possibilities in gene function, drug screening, and human disease research.
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Strain Name：C57BL/6Smoc-Cdkn2bem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2115067
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Strain Name：C57BL/6Smoc-Cdkn2Bem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190621
Research Application：This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression.
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Strain Name：C57BL/6Smoc-Cdkn2cem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-205110
Disease Connection：medulloblastoma
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Strain Name：C57BL/6Smoc-Cdkn2Cem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-2114003
Disease Connection：medulloblastoma
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Strain Name：C57BL/6Smoc-Cdkn2Dem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-2107647
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Strain Name：C57BL/6Smoc-Cdnfem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-205546
Research Application：secreted protein
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