R26-CAG-LSL-GqDREADD(hM3Dq)-2A-mCitrine

Nomenclature

C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-HA-GqDREADD(hM3Dq)-P2A-mCitrine-WPRE-polyA)Smoc

Cat. NO.

NM-KI-190106

Strain State

Repository Live

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Gene Summary

Gene Symbol
Gt(ROSA)26Sor

Synonyms

R26，ROSA26，AV258896，Gtrgeo26，Gtrosa26，Thumpd3as1

NCBI ID

14910

MGI ID

104735

Ensembl ID

ENSMUSG00000086429

Pubmed

Gt(ROSA)26Sor

Model Description

将CAG-LSL-HA-GiDREADD（hM3Dq)-P2A-mCitrine-WPRE-polyA插入到小鼠Rosa26基因中。
Research Application：属于化学遗传学元件，用于神经科学研究，药物（叠氮平-N-氧化物，CNO）诱导后GqDREADD(hM3Dq)可刺激神经元的活性。但在不同细胞类型中，诱导效果不一样。

Validation Data

hM3Dq.png

Fig1.荧光检测Dppa3-Cre+/-;R26-hM3Dq-2A-mCitrine+/- 小鼠脑内mCitrine的表达。

Dppa3-Cre+/-小鼠与R26-hM3Dq-2A-mCitrine+/- 小鼠进行交配获得的双阳性小鼠，取脑组织进行荧光显微镜拍照。实验结果显示R26-hM3Dq-2A-mCitrine小鼠可以在脑组织神经元中正确表达。

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