Cd274-KO(2)

Nomenclature

C57BL/6Smoc-Cd274em2Smoc

Cat. NO.

NM-KO-18044

Strain State

Repository Live

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Gene Summary

Gene Symbol
Cd274

Synonyms

B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik

NCBI ID

60533

MGI ID

1926446

Ensembl ID

ENSMUSG00000016496

Pubmed

Cd274

Human Ortholog

CD274

Model Description

Cd274 gene is also called B7-H1, Pdcd1lg1 or PD-L1. The PD-L1-KO(2) mouse model was obtained by deleting the Exon 3-5 region of mouse Cd274 gene. While PD-L1-KO(Stock No.NM-KO-00104) mice have been pulled from shelves for some reasons.
Research Application：inflammatory,immune system

Validation Data

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Fig1. Expression of PD-L1 in peritoneal macrophages, spleen cells and bone marrow cells from PD-L1 knockout mice is detected by FACS.  The results showed that the expression of PD-L1 can not be detected in peritoneal macrophages, spleen cells and bone marrow cells of homozygous mice.

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