hCD40/h4-1BB(2)

Nomenclature

C57BL/6Smoc-Cd40tm1(hCD40)Tnfrsf9tm2(TNFRSF9)Smoc

Cat. NO.

NM-HU-200256

Strain State

Embryo cryopreservation

Export PDF

Model Description

该品系是通过hCD40(NM-HU-00076)和h4-1BB(2)(NM-HU-190077)小鼠交配获得。
Research Application：肿瘤研究；免疫治疗；药物筛选

Validation Data

4-1BB&CD40-1.png4-1BB&CD40-2.png

图1 CD40&4-1BB双人源化小鼠 MC38 荷瘤模型体内抗肿瘤药效验证。CD40&4-1BB双人源化纯合子小鼠接种B16F10细胞系，肿瘤生长至约80mm3 时，随机将动物分组为对照组和不同组合的治疗组（n=6）。

结果显示：针对人源CD40的selicrelumab抗体和针对人源4-1BB的urelumab 抗体联合使用，有非常显著的抗肿瘤效果，证明CD40&4-1BB-HU 双人源化小鼠是一个很好的验证针对人CD40&4-1BB-HU 抗体联合药效的体内模型。

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Workshop：Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

Learn more