hHER2
Nomenclature
C57BL/6Smoc-Erbb2em1(hERBB2)Smoc
Cat. NO.
NM-HU-200115
Strain State
Repository Live
Gene Summary
Gene Symbol
Erbb2
Model Description
Validation Data
Fig1. Detection of HER2 expression by RT-PCR.
Wild type: only one band at 375 bp with primers F1/R1 (mHer2);
Homozygous: one band at 223 bp with primers F2/R2 (hHER2).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig2. Detection of HER2 expression in homozygous hHER2 mice by Western Blot.
(Note: The HER2 antibody cross-reacted with mHER2 and humanized HER2)
Fig.3 In vivo efficacy assessment of Herceptin in hHER2 mice bearing B16F10-HER2 syngeneic tumor.
Body weight (A) and Tumor volume (B) were measured of hHER2 mice.
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