Rag2-KO/hHER2

Nomenclature

C57BL/6Smoc-Rag2em2Erbb2tm1(hHER2)Smoc

Cat. NO.

NM-HU-234873

Strain State

Repository Live

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Gene Summary

Gene Symbol
Erbb2

Synonyms

Neu; HER2; HER-2; c-neu; Erbb-2; c-erbB2; l11Jus8; mKIAA3023

NCBI ID

13866

MGI ID

95410

Ensembl ID

ENSMUSG00000062312

Pubmed

Erbb2

Human Ortholog

ERBB2

Model Description

The hHER2(NM-HU-200115) was crossed with Rag2-KO(NM-KO-190429) to generate Rag2-KO/hHER2 mice.

Validation Data

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Fig.1 Subcutaneous xenograft tumor growth of NCI-N87 in Rag2-KO/hHER2 mouse model. 

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Fig 2. Body weight change and means of body weight of Rag2-KO/hHER2 mouse model after tumor inoculation. 

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Fig.3 In vivo efficacy of Disitamab Vedotin on Rag2-KO/hHER2 mice bearing NCI-N87 tumor (n=2-6, female, 6-8 weeks old).

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