hANGPTL3(5)

Nomenclature

C57BL/6Smoc-Angptl3tm3(hANGPTL3)Smoc

Cat. NO.

NM-HU-230047

Strain State

Repository Live

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Gene Summary

Gene Symbol
Angptl3

Synonyms

hypl

NCBI ID

30924

MGI ID

1353627

Ensembl ID

ENSMUSG00000028553

Pubmed

Angptl3

Human Ortholog

ANGPTL3

Model Description

The endogenous mouse Angptl3 gene was replaced by human ANGPTL3 gene.

Validation Data

image.png

Fig.1 Detection of ANGPTL3 expression in liver of HO hANGPTL3(5) mice by RT-PCR. （male， 8wks）

Wild type: only one band at 155 bp with primers F1/R1(mAngptl3);

Homozygous: only one band at 155 bp with primers F2/R2(hANGPTL3).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human ANGPTL3 expression in serum by ELISA (n=3). 

Abbr.  HO, homozygous; WT, wild type; N.D. not detected.

image.png

Table.1 Blood biochemical test of WT mice and hANGPTL3(5) knockin mice. 

Values are expressed as mean±SEM.

Abbr. HO, homozygous; WT, wild type.

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