hAPOE3

Nomenclature

C57BL/6Smoc-Apoetm3(hAPOE3)Smoc

Cat. NO.

NM-HU-190003

Strain State

Repository Live

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Gene Summary

Gene Symbol
Apoe

Synonyms

Apo-E; AI255918

Chromosome

7

NCBI ID

11816

MGI ID

88057

Ensembl ID

ENSMUSG00000002985

Pubmed

Apoe

Human Ortholog

APOE

Model Description

This APOE3 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE3 corresponding sequence by homologous recombination.
Research Application：Cardiovascular disease

Validation Data

Validation data

Apoe3-2.png

Fig1. Genotyping of WT 、KO &  Humanized mice by PCR.

Primer P1/2 Wild type = 342 bp

Primer P3/4 mutant = 332 bp

M：100bp Plus DNA ladder.

image.png

Fig2. Western blot analysis of  APOE3 protein from  WT、KO & Humanized mice. 

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