Wap-IRES-Cre

Nomenclature

C57BL/6Smoc-Wapem1(IRES-Cre-WPRE-polyA)Smoc

Cat. NO.

NM-KI-200064

Strain State

Repository Live

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Gene Summary

Gene Symbol
Wap

Synonyms

-

Chromosome

11

NCBI ID

22373

MGI ID

98943

Ensembl ID

ENSMUSG00000000381

Pubmed

Wap

Human Ortholog

WAP

Model Description

A IRES-Cre-WPRE-polyA expression cassette was knocked into the Wap gene stop codon site.
Research Application：These mice express cre recombinase from the Wap locus. By mating the reporter mice with Cre-expressing mice, reporter gene expression can be detected in the mammary gland epithelial cells of the lactating mouse. This strain may be useful for in the research of breast carcinoma.

Validation Data

Wap-IRES-Cre-1.png

Fig.1 Cre-mediated recombination in the mammary gland of female WapCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the mammary gland epithelial cells of the lactating WapCre/+; Rosa26tdTomato/+ mouse. 

Wap-IRES-Cre-2.png

Fig.2 Detection of tdTomato(red) in various tissues of WapCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the some cells of salivary glands and mammary glands of the lactating mouse. Tdtomato can not be detected in the brain, thymus, pituitary gland, heart, lung, liver, stomach, kidney, brown fats, colon, pancreas, muscle, testis and epididymis. (For more detailed information please contact our technical advisor.)

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