Nkx3-1-IRES-Cre

Nomenclature

C57BL/6JSmo-Nkx3-1em1(IRES-iCre)Smoc

Cat. NO.

NM-KI-200171

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Nkx3-1

Synonyms

Bax; NKX3A; NKX3.1; Nkx-3.1; bagpipe

Chromosome

14

NCBI ID

18095

MGI ID

97352

Ensembl ID

ENSMUSG00000022061

Pubmed

Nkx3-1

Human Ortholog

NKX3-1

Model Description

A IRES-iCre expression cassette was knocked into the Nkx3-1 gene stop codon site. Nkx3-1 (NK3 homeobox 1) encodes prostate-specific homeodomain protein. The gene product is a key element in protecting prostate epithelial cells from DNA damage. This strain is useful for studying prostate.
Research Application：Cre recombinase tool; Prostate

Validation Data

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Fig. 1 Cre-mediated recombination in the prostate of Nkx3-1Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the atrium derived from Nkx3-1Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of Nkx3-1Cre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination can be detected in some cells of the prostate, brain, liver, kidney, salivary gland, stomach, thymus, colon, muscle, pancreas, brown fat, intestine and in individual cells of the spleen. (For more detailed information please contact our technical advisor.)


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