hIGF1R(2)

Nomenclature

C57BL/6Smoc-Igf1rtm(hIGF1R)Smoc

Cat. NO.

NM-HU-230053

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol
Igf1r

Model Description

The endogenous mouse Igf1r gene was replaced by human IGF1R gene.

Validation Data

image.png

Fig.1 Detection of human IGF1R expression in female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr. M, marker; WT, wild type; HO, Homozygous.

image.png

Fig.2 Detection of hIGF1R expression in the lung of female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.3 Detection of hIGF1R expression in the brain of female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.4 Detection of hIGF1R expression in the kidney of female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.5 Detection of lymphcytes subsets in the spleen of female hIGF1R(2) knockin mice by FACS. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.6 Detection of myeloid cells in the spleen of female hIGF1R(2) knockin mice by FACS. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Workshop:Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

Learn more