Models

Conditional Knockouts

In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.

mouse
Strain Name:C57BL/6Smoc-Cldnd1em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
mouse
Strain Name:C57BL/6Smoc-Cldnd2em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
mouse
Strain Name:C57BL/6JSmo-Clec10aem1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-240776
mouse
Strain Name:C57BL/6JSmo-Clec11aem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-232253
mouse
Strain Name:C57BL/6JSmo-Clec12aem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-231303
mouse
Strain Name:C57BL/6JSmo-Clec12bem1(flox)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-CKO-2108208
mouse
Strain Name:C57BL/6JSmo-Clec14atm(flox)/Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-230177
mouse
Strain Name:C57BL/6Smoc-Clec16aem1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
mouse
Strain Name:B6;129S-Clec18atm1(flox)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-CKO-00006
mouse
Strain Name:C57BL/6JSmo-Clec1aem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-234192
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