Models

Conditional Knockouts

In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.

mouse
Strain Name:C57BL/6JSmo-Ucn3em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-241784
mouse
Strain Name:C57BL/6JSmo-Ucp1em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-226424
mouse
Strain Name:C57BL/6Smoc-Ucp2em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
mouse
Strain Name:C57BL/6JSmo-Ucp3em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-241446
mouse
Strain Name:C57BL/6Smoc-Uevldem1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
mouse
Strain Name:C57BL/6Smoc-Ufc1em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
mouse
Strain Name:C57BL/6Smoc-Ufd1em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
mouse
Strain Name:C57BL/6JSmo-Ufl1em(flox)/Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-220576
mouse
Strain Name:C57BL/6JSmo-Ufm1em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-250720
mouse
Strain Name:C57BL/6JSmo-Ufsp1em1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-252703
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