MC38-hROR1

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Strain Information

Cell Line

MC38-Igs2em1(hROR1)Smoc

Cat. NO.

NM-S13-TM58

Model Description

A ROR1 expression cassette was knocked into the H11 locus.

Strain State

Validation of target gene expression completed

Validation Data

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Fig.1 hROR1 expression on in vitro cultured cells of MC38-hROR1

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Fig.2 In vivo validation of MC38-hROR1 in C57BL/6 mice.C57BL/6 mice were inoculated with MC38-hROR1 subcutaneously at 3×106 cells/mouse inoculum for tumor development. The day of vaccination for mice is defined as Day 0, and tumor measurement and weight measurement begin on the 6th day after vaccination, twice a week.

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Fig.3 hROR1 expression in tumors after in vivo growth of MC38-hROR1 in wild type C57BL/6 mice.The tumors were collected at day 48 post tumor cell inoculation. When the MTV reaches 1000-1500mm3, take 2 tubes from each group and send them to FACS for testing (Markers: L/D, mCD45, hROR1).

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