SCID
Nomenclature
SCID/NifdcSmoc
Cat. NO.
SM-015
Strain State
Repository Live
Model Description
SCID mice, also known as Severe Combined Immune Deficient mice, were first discovered in 1983 by Bosma M.J. from the C.B-17/Icr inbred strain of mice. This condition is caused by a mutation in a single recessive gene located on chromosome 16, also referred to as the SCID gene. SCID mice are a congenic strain of C.B-17/lcrJ, with white fur. This strain exhibits severe combined immune deficiency, characterized by the absence of functional B cells and T lymphocytes. Most homozygotes lack detectable levels of IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA. Additionally, the thymus, lymph nodes, and splenic follicles of these mice are virtually devoid of lymphocytes. However, SCID mice possess normal natural killer (NK) cells, macrophages, and granulocytes. SCID mice are commonly used for the transplantation of allogeneic or xenogeneic tissues and are ideal models for cell transplantation experiments.
Validation Data
Fig 1. Growth curve of SCID mice (n=10).
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Fig 2. Hematological analysis of SCID mice.
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