SCID

SCID mice, or severe combined immunodeficiency mice, were first identified in 1983 by Bosma M.J. in the United States from the C.B.-17/Icr inbred strain. This condition arises from a mutation in a single recessive gene located on chromosome 16, also termed the SCID gene. SCID mice constitute an inbred homozygous line of C.B-17/IcrJ, exhibiting white coat colouration. This strain displays severe combined immunodeficiency, characterised by the absence of B-cell and T-lymphocyte function. Most homozygotes lack detectable levels of IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA, and their thymus, lymph nodes, and splenic follicles contain almost no lymphocytes. However, the strain possesses normal NK cells, macrophages, and granulocytes. SCID mice are frequently used for inoculation with allogeneic or xenogeneic grafts, making them an ideal model for cell transplantation experiments.

Fig 1. Growth curve of SCID mice (n=460).

Fig 2. Hematological analysis of SCID mice.