Abca4-KO

Nomenclature

C57BL/6Smoc-Abca4em1Smoc

Cat. NO.

NM-KO-2104711

Strain State

Repository Live

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Gene Summary

Gene Symbol
Abca4

Synonyms

RmP; Abcr; Abc10; AW050280; D430003I15Rik

NCBI ID

11304

MGI ID

109424

Ensembl ID

ENSMUSG00000028125

Pubmed

Abca4

Human Ortholog

ABCA4

Model Description

Exon 2 of Abca4 gene was deleted to generate Abca4 knockout mice.

Validation Data

image.png

Fig.1 Detection of Abca4 expression in the lung, eye, pallium, liver and kidney by qPCR. (n=5, 3 male mice and 2 female mice in each group)

Abbr. HO, homozygous; WT, wild type.

image.png

Fig. 2 Detection of Cd59, Cfi, Cfh, Cfp, Cfb, C3 and C1s expression in eyes by qPCR (3 male mice in each  group, Mean ± SEM. t-test, *P < 0.05, ns: no significance). 

Abbr. HO, homozygous; WT, wild type.

image.png

Fig. 3 Detection of Cd59, Cfi, Cfh, Cfp, Cfb, C3 and C1s expression in eyes by qPCR (2 female mice in each  group, Mean ± SEM). 

Abbr. HO, homozygous; WT, wild type.

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