hIL4-Tg(NMG)
Nomenclature
NOD-PrkdcscidIl2rgem1Tg(hIL4)Smoc
Cat. NO.
NM-KI-215004
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
IL4
Model Description
These transgenic mice carry humanized IL4.
Validation Data
Fig1. Detection of hIL4 expression by RT-PCR.
Heterozygous: one band at 223 bp with primers F1/R1(hIL4);
Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig 2. Detection of hIL4 expression in serum by ELISA.
Abbr. HO, homozygous; HE, heterozygous; WT, wild type.、
Fig 3. Body weight growth curve of huPBMC-NMG-hIL4 mice.
Fig 4. Survival rate of huPBMC-NMG-hIL4 mice.
Fig 5. GvHD scores of huPBMC-NMG-hIL4 mice.
Fig 6. Percentage of hCD45-positive cells in peripheral blood of huPBMC-NMG-hIL4 mice.
Fig 7. Flow analysis of peripheral blood lymphocyte subpopulations in the huPBMC-NMG-hIL4 model. Human PBMCs (1E7) were injected intravenously into hIL4-Tg(NMG) mice (female, 6-8 weeks old, n=10). Blood from mice at different time points after implantation of human PBMCs was taken for flow cytometric analysis.
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